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dc.contributor.authorSanabria de la Torre, Raquel 
dc.contributor.authorGarcía Fontana, Cristina 
dc.contributor.authorGonzález Salvatierra, Sheila
dc.contributor.authorAndújar Vera, Francisco Luis
dc.contributor.authorMartínez Heredia, Luis
dc.contributor.authorGarcía Fontana, Beatriz 
dc.contributor.authorMuñoz Torres, Manuel Eduardo 
dc.date.accessioned2022-07-29T08:18:24Z
dc.date.available2022-07-29T08:18:24Z
dc.date.issued2022-06-23
dc.identifier.citationSanabria-de la Torre, R... [et al.]. The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2022, 23, 6995. [https://doi.org/10.3390/ijms23136995]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/76422
dc.description.abstractVascular complications are the leading cause of morbidity and mortality among patients with type 2 diabetes mellitus (T2DM). These vascular abnormalities result in a chronic hyperglycemic state, which influences many signaling molecular pathways that initially lead to increased oxidative stress, increased inflammation, and endothelial dysfunction, leading to both microvascular and macrovascular complications. Endothelial dysfunction represents the initial stage in both types of vascular complications; it represents “mandatory damage” in the development of microvascular complications and only “introductory damage” in the development of macrovascular complications. Increasing scientific evidence has revealed an important role of the Wnt pathway in the pathophysiology of the vascular wall. It is well known that the Wnt pathway is altered in patients with T2DM. This review aims to be an update of the current literature related to the Wnt pathway molecules that are altered in patients with T2DM, which may also be the cause of damage to the vasculature. Both microvascular complications (retinopathy, nephropathy, and neuropathy) and macrovascular complications (coronary artery disease, cerebrovascular disease, and peripheral arterial disease) are analyzed. This review aims to concisely concentrate all the evidence to facilitate the view on the vascular involvement of the Wnt pathway and its components by highlighting the importance of exploring possible therapeutic strategy for patients with T2DM who develop vascular pathologies.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III European Commission PI18-00803 PI21-01069 PI18-01235 CD20/00022 FI19/00118es_ES
dc.description.sponsorshipEuropean Commissiones_ES
dc.description.sponsorshipJunta de Andalucia PI-0268-2019es_ES
dc.description.sponsorshipUniversity of Granadaes_ES
dc.description.sponsorshipEuropean Commission 8110es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCardiovascular diseasees_ES
dc.subjectMicrovascular diseasees_ES
dc.subjectMacrovascular diseasees_ES
dc.subjectType 2 diabetes mellituses_ES
dc.subjectWnt pathwayes_ES
dc.titleThe Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellituses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.3390/ijms23136995
dc.type.hasVersionVoRes_ES


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