The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus
Metadatos
Mostrar el registro completo del ítemAutor
Sanabria de la Torre, Raquel; García Fontana, Cristina; González Salvatierra, Sheila; Andújar Vera, Francisco Luis; Martínez Heredia, Luis; García Fontana, Beatriz; Muñoz Torres, Manuel EduardoEditorial
MDPI
Materia
Cardiovascular disease Microvascular disease Macrovascular disease Type 2 diabetes mellitus Wnt pathway
Fecha
2022-06-23Referencia bibliográfica
Sanabria-de la Torre, R... [et al.]. The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2022, 23, 6995. [https://doi.org/10.3390/ijms23136995]
Patrocinador
Instituto de Salud Carlos III European Commission PI18-00803 PI21-01069 PI18-01235 CD20/00022 FI19/00118; European Commission; Junta de Andalucia PI-0268-2019; University of Granada; European Commission 8110Resumen
Vascular complications are the leading cause of morbidity and mortality among patients
with type 2 diabetes mellitus (T2DM). These vascular abnormalities result in a chronic hyperglycemic
state, which influences many signaling molecular pathways that initially lead to increased oxidative
stress, increased inflammation, and endothelial dysfunction, leading to both microvascular and
macrovascular complications. Endothelial dysfunction represents the initial stage in both types of
vascular complications; it represents “mandatory damage” in the development of microvascular
complications and only “introductory damage” in the development of macrovascular complications.
Increasing scientific evidence has revealed an important role of the Wnt pathway in the pathophysiology
of the vascular wall. It is well known that the Wnt pathway is altered in patients with T2DM.
This review aims to be an update of the current literature related to the Wnt pathway molecules
that are altered in patients with T2DM, which may also be the cause of damage to the vasculature.
Both microvascular complications (retinopathy, nephropathy, and neuropathy) and macrovascular
complications (coronary artery disease, cerebrovascular disease, and peripheral arterial disease) are
analyzed. This review aims to concisely concentrate all the evidence to facilitate the view on the
vascular involvement of the Wnt pathway and its components by highlighting the importance of
exploring possible therapeutic strategy for patients with T2DM who develop vascular pathologies.