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dc.contributor.authorGutiérrez Bautista, Juan Francisco 
dc.contributor.authorRodríguez Nicolás, Antonio
dc.contributor.authorRosales Castillo, Antonio
dc.contributor.authorLópez Ruz, Miguel Ángel 
dc.contributor.authorMartín Casares, Antonia María
dc.contributor.authorFernández Rubiales, Alonso
dc.contributor.authorAnderson, Per Olof 
dc.contributor.authorGarrido Torres-Puchol, Federico 
dc.contributor.authorRuiz-Cabello Osuna, Francisco 
dc.contributor.authorLópez Nevot, Miguel Ángel 
dc.date.accessioned2022-07-08T10:16:17Z
dc.date.available2022-07-08T10:16:17Z
dc.date.issued2021-08-25
dc.identifier.citationJuan Francisco Gutiérrez-Bautista... [et al.]. Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients, Journal of Microbiology, Immunology and Infection, Volume 55, Issue 3, 2022, Pages 421-427, ISSN 1684-1182, [https://doi.org/10.1016/j.jmii.2021.08.009]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/75889
dc.description.abstractBackground: Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19. Methods: We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one of the largest HLA-typed patient cohort to date. Results: Our results show that there is no relationship between HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19. Conclusion: Our results may contribute to resolve the contradictory data on the role of HLA polymorphisms in COVID-19 infection.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III - FEDER funds (European Union) PI 16/00752es_ES
dc.description.sponsorshipJunta de Andalucia CTS-143 C-0013-2018es_ES
dc.description.sponsorshipRAFER S.L.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHLA polymorphismses_ES
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.titleStudy of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1016/j.jmii.2021.08.009
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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