Show simple item record

dc.contributor.authorMesas Hernández, Cristina 
dc.contributor.authorMartínez Martínez, Rosario 
dc.contributor.authorDoello, Kevin
dc.contributor.authorOrtiz Quesada, Raúl 
dc.contributor.authorLópez-Jurado Romero De La Cruz, María 
dc.contributor.authorQuiñonero Muñoz, Francisco José 
dc.contributor.authorPrados Salazar, José Carlos 
dc.contributor.authorPorres Foulquie, Jesús María 
dc.contributor.authorMelguizo Alonso, Consolación
dc.identifier.citationC. Mesas... [et al.]. In vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer models, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112883, ISSN 0753-3322, []es_ES
dc.description.abstractEuphorbia lathyris seeds have been used to treat various medical conditions. We previously reported that ethanolic extract from the defatted seed of Euphorbia lathyris (EE) (variety S3201) possesses a potent in vitro antitumor activity against colon cancer (CRC) cell lines. However, the effects of EE on CRC in vivo models and its possible preventive activity have not been elucidated. The aim of this study is to develop an in vivo study to corroborate its efficacy. For this purpose, two tumor induction models have been developed. In orthotopic xenograft model, it has been shown that EE reduces tumor size without hematological toxicity. The ethanolic extract induced an intense apoptosis in tumors mediated by caspase 3. Using the Azoxymethane/Dextran Sulfate Sodium model, a reduction of dysplastic polyps has been demonstrated, showing its preventive power. Furthermore, EE promoted the presence of an eubiotic microbiotal environment in the mucosa of the colon and induced an increase in antioxidant enzyme activity. This fact was accompanied by a modulation of cytokine expression that could be related to its protective mechanism. Therefore, although further experiments will be necessary to determine its applicability in the treatment of CRC, ES could be a new prevention strategy as well as treatment for this type of tumor, being a powerful candidate for future clinical trials.es_ES
dc.description.sponsorshipSpanish Government RTC-2017-6540-1 RTC2019-006870-1es_ES
dc.description.sponsorshipJunta de Andalucia P18-TP-1420es_ES
dc.description.sponsorshipEuropean Commission AGR145 CTS-107es_ES
dc.description.sponsorshipAndalusian Governmentes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectColon canceres_ES
dc.subjectEuphorbia lathyrises_ES
dc.subjectAOM/DSS modeles_ES
dc.subjectOrthotopic xenograft modeles_ES
dc.subjectOxidative stress detoxification enzymeses_ES
dc.titleIn vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer modelses_ES

Files in this item


This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España