An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans
Metadatos
Mostrar el registro completo del ítemAutor
Romero Márquez, José Manuel; Navarro Hortal, María Dolores; Jiménez Trigo, Victoria; Vera Ramírez, Laura; Forbes Hernández, Tamara Yuliett; Esteban Muñoz, Adelaida; Sánchez González, Cristina; Quiles Morales, José LuisEditorial
Elsevier
Materia
Alzheimer disease DAF-16/FOXO HSP-16.2 IIS pathway RNAi SKN-1/NRF2
Fecha
2022-03-08Referencia bibliográfica
Jose M. Romero-Márquez... [et al.]. An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans, Food and Chemical Toxicology, Volume 162, 2022, 112914, ISSN 0278-6915, [https://doi.org/10.1016/j.fct.2022.112914]
Patrocinador
FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento B-AGR-193-UGR18; MCIN/AEI/FEDER "Una manera de hacer Europa" PID2019-106778RB-I00Resumen
Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study
was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as
well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated
in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against
Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert
toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and
tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi
technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling
pathway, as well as HSP-16.2 overexpression were involved.