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[18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function
dc.contributor.author | Triviño Ibáñez, Eva María | |
dc.contributor.author | Jiménez Rodríguez, Beatriz María | |
dc.contributor.author | Rudolphi Solero, Teodoro | |
dc.contributor.author | García Rivero, Encarnación Yolanda | |
dc.contributor.author | Rodríguez Fernández, Antonio | |
dc.contributor.author | Llamas Elvira, José Manuel | |
dc.contributor.author | Gómez Río, Manuel | |
dc.contributor.author | Morales García, Concepción | |
dc.date.accessioned | 2022-05-09T11:37:35Z | |
dc.date.available | 2022-05-09T11:37:35Z | |
dc.date.issued | 2022-03-29 | |
dc.identifier.citation | Triviño-Ibáñez, E.M... [et al.]. [18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function. Diagnostics 2022, 12, 835. [https://doi.org/10.3390/diagnostics12040835] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/74755 | |
dc.description.abstract | SARS-CoV-2 virus infects organs other than the lung, such as mediastinal lymph nodes, spleen, and liver, but, to date, metabolic imaging studies obtained in short-term follow-ups of patients hospitalized with severe COVID-19 infection are rare. Our objective was to evaluate the usefulness of [18F]FDG-PET/CT in the short-term follow-up of patients admitted for COVID-19 pneumonia and to explore the association of the findings with clinical prognostic markers. The prospective study included 20 patients with COVID-19 pneumonia (November 2020–March 2021). Clinical and laboratory test findings were gathered at admission, 48–72 h post-admission, and 2–3 months post-discharge, when [18F]FDG-PET/CT and respiratory function tests were performed. Lung volumes, spirometry, lung diffusion capacity for carbon monoxide (DLCO), and respiratory muscle strength were measured. Volumetric [18F]FDG-PET/CT results were correlated with laboratory and respiratory parameters. Eleven [18F]FDG-PET/CT (55%) were positive, with hypermetabolic mediastinal lymphadenopathy in 90.9%. Mediastinal lesion’s SUVpeak was correlated with white cells’ count. Eleven (55%) patients had impaired respiratory function, including reduced DLCO (35%). SUVpeak was correlated with %predicted-DLCO. TLG was negatively correlated with %predicted- DLCO and TLC. In the short-term follow-up of patients hospitalized for COVID-19 pneumonia, [18F]FDG-PET/CT findings revealed significant detectable inflammation in lungs and mediastinal lymph nodes that correlated with pulmonary function impairment in more than half of the patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | COVID-19 | es_ES |
dc.subject | [18F]FDG-PET/CT | es_ES |
dc.subject | Respiratory function test | es_ES |
dc.subject | Inflammatory | es_ES |
dc.subject | Complications | es_ES |
dc.subject | SARS-CoV-2 | es_ES |
dc.title | [18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/diagnostics12040835 | |
dc.type.hasVersion | VoR | es_ES |