Mostrar el registro sencillo del ítem
Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females
dc.contributor.author | Straat, Maaike E. | |
dc.contributor.author | Alcántara Alcántara, Juan Manuel | |
dc.contributor.author | Méndez Gutiérrez, Andrea | |
dc.date.accessioned | 2022-03-25T13:15:11Z | |
dc.date.available | 2022-03-25T13:15:11Z | |
dc.date.issued | 2022-02-18 | |
dc.identifier.citation | Maaike E Straat... [et al.]. Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females, The Journal of Clinical Endocrinology & Metabolism, 2022;, dgac094, [https://doi.org/10.1210/clinem/dgac094] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/73788 | |
dc.description | This work was supported by the Fundacion Alfonso Martin Escudero (to B.M.T), by the Dutch Heart Foundation (2017T016 to S.K.), by the Dutch Society for Diabetes Research (NVDO; Prof. dr. J. Terpstra Award to S.K.), the Dutch Diabetes Foundation (2015.81.1808 to M.R.B.) and the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE and CVON2017 GENIUS-2 to P.C.N.R.) | es_ES |
dc.description.abstract | Context: Cold exposure mobilizes lipids to feed thermogenic processes in organs, including brown adipose tissue (BAT). In rodents, BAT metabolic activity exhibits a diurnal rhythm, which is highest at the start of the wakeful period. Objective: We investigated whether cold-induced thermogenesis displays diurnal variation in humans and differs between the sexes. Methods: This randomized crossover study included 24 young and lean male (n = 12) and female (n = 12) participants who underwent 2.5-hour personalized cooling using water-perfused mattresses in the morning (7:45 am) and evening (7:45 pm), with 1 day in between. We measured energy expenditure (EE) and supraclavicular skin temperature in response to cold exposure. Results: In males, cold-induced EE was higher in the morning than in the evening (+54% ± 10% vs +30% ± 7%; P = 0.05) but did not differ between morning and evening in females (+37% ± 9% vs +30% ± 10%; P = 0.42). Only in males, supraclavicular skin temperature upon cold increased more in morning than evening (+0.2 ± 0.1 °C vs −0.2 ± 0.2 °C; P = 0.05). In males, circulating free fatty acid (FFA) levels were increased after morning cold exposure, but not evening (+90% ± 18% vs +9% ± 8%; P < 0.001). In females, circulating FFA (+94% ± 21% vs +20% ± 5%; P = 0.006), but also triglycerides (+42% ± 5% vs +29% ± 4%, P = 0.01) and cholesterol levels (+17% ± 2% vs 11% ± 2%; P = 0.05) were more increased after cold exposure in morning than in evening. Conclusion: Cold-induced thermogenesis is higher in morning than evening in males; however, lipid metabolism is more modulated in the morning than the evening in females. | es_ES |
dc.description.sponsorship | Fundacion Alfonso Martin Escudero | es_ES |
dc.description.sponsorship | Netherlands Heart Foundation 2017T016 CVON2014-02 ENERGISE CVON2017 GENIUS-2 | es_ES |
dc.description.sponsorship | Dutch Society for Diabetes Research (NVDO) | es_ES |
dc.description.sponsorship | Dutch Diabetes Foundation 2015.81.1808 | es_ES |
dc.description.sponsorship | Netherlands Cardiovascular Research Initiative | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Brown adipose tissue | es_ES |
dc.subject | Cardiometabolic health | es_ES |
dc.subject | Cold stimulus | es_ES |
dc.subject | Circadian rhythm | es_ES |
dc.subject | Gender differences | es_ES |
dc.subject | Metabolism | es_ES |
dc.title | Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1210/clinem/dgac094 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |