From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats
Metadatos
Mostrar el registro completo del ítemAutor
Ruiz Leyva, Leandro; Vázquez-Ágredos, Ana; Jiménez García, Ana María; López Guarnido, Olga; Pla Martínez, Antonio; Marcos Pautassi, Ricardo; Morón Henche, Ignacio; Cendán Martínez, Cruz MiguelEditorial
Wiley
Materia
Binge drinking Binge eating Ethanol Naltrexone Self-administration
Fecha
2022-02-23Referencia bibliográfica
Ruiz-Leyva L, Vázquez- Agredos A, Jiménez-García AM, et al. From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol selfadministration in male rats. Addiction Biology. 2022;27(2): e13153. [doi:10.1111/adb.13153]
Patrocinador
Junta de Andalucía, Grant/Award Numbers: CTS109, B-CTS-422-UGR18; Ministerio de Universidades, Spain, Grant/Award Number: FPU18/05012; Ministry of Science and Innovation, Grant/Award Number: MICIUPID2020- 114269GB-I00; Spanish Ministry of Health (Government Delegation for the National Plan on Drugs), Grant/Award Number: PNSD 2020-049Resumen
Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self-administration co-occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two-bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 gEtOH/kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within-group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two-bottle choice test. Altogether, this self-administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive-like behaviours.