@misc{10481/73461,
year = {2022},
month = {2},
url = {http://hdl.handle.net/10481/73461},
abstract = {Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self-administration co-occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two-bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 gEtOH/kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within-group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two-bottle choice test. Altogether, this self-administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive-like behaviours.},
organization = {Junta de Andalucía, Grant/Award Numbers:
CTS109, B-CTS-422-UGR18},
organization = {Ministerio de
Universidades, Spain, Grant/Award Number:
FPU18/05012},
organization = {Ministry of Science and
Innovation, Grant/Award Number: MICIUPID2020-
114269GB-I00},
organization = {Spanish Ministry of
Health (Government Delegation for the
National Plan on Drugs), Grant/Award
Number: PNSD 2020-049},
publisher = {Wiley},
keywords = {Binge drinking},
keywords = {Binge eating},
keywords = {Ethanol},
keywords = {Naltrexone},
keywords = {Self-administration},
title = {From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats},
doi = {10.1111/adb.13153},
author = {Ruiz Leyva, Leandro and Vázquez-Ágredos, Ana and Jiménez García, Ana María and López Guarnido, Olga and Pla Martínez, Antonio and Marcos Pautassi, Ricardo and Morón Henche, Ignacio and Cendán Martínez, Cruz Miguel},
}