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Differential iNKT and T Cells Activation in Non-Alcoholic Fatty Liver Disease and Drug-Induced Liver Injury
dc.contributor.author | Caballano Infantes, Estefanía | |
dc.contributor.author | Ruiz-Cabello Osuna, Francisco | |
dc.date.accessioned | 2022-03-08T07:33:47Z | |
dc.date.available | 2022-03-08T07:33:47Z | |
dc.date.issued | 2021-12-28 | |
dc.identifier.citation | Caballano-Infantes, E... [et al.]. Differential iNKT and T Cells Activation in Non-Alcoholic Fatty Liver Disease and Drug-Induced Liver Injury. Biomedicines 2022, 10, 55. [https://doi.org/10.3390/biomedicines10010055] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/73198 | |
dc.description | This work was supported in part by a grant from the Instituto de Salud Carlos III (Spain) (PI18/01804, PI19/00883, PI21/01248), from the Consejeria de Economia, Conocimiento, Empresas y Universidad (Junta de Andalucia, Spain) (UMA18-FEDERJA-194, PI18-RT-3364), and from the Consejeria de Salud (Junta de Andalucia, Spain) (PI-0285-2016). This study has been co-funded by FEDER funds ("A way to make Europe") ("Andalucia se mueve con Europa"). | es_ES |
dc.description.abstract | Background: Non-alcoholic fatty liver disease (NAFLD) and idiosyncratic drug-induced liver injury (DILI) could share molecular mechanisms involving the immune system. We aimed to identify activation immunological biomarkers in invariant natural killer T (iNKT) and CD4/CD8+ T cells in NAFLD and DILI. Methods: We analyzed the activation profile (CD69, CD25, and HLA-DR) and natural killer group 2 member D (NKG2D) on iNKT cells, and CD4/CD8 T cells in peripheral blood mononuclear cells from NAFLD, with or without significant liver fibrosis, and DILI patients. Results: There was an increase in iNKT cells in NAFLD patients compared to DILI or control subjects. Regarding the cellular activation profile, NAFLD with significant liver fibrosis (F >= 2) displayed higher levels of CD69+iNKT cells compared to NAFLD with none or mild liver fibrosis (F <= 1) and control patients. CD69+iNKT positively correlated with insulin resistance, aspartate aminotransferase (AST) level, liver fibrosis-4 index (FIB4) and AST to Platelet Ratio Index (APRI). DILI patients showed an increase in CD69+ and HLA-DR+ in both CD4+ and CD8+ T cells, detecting the most relevant difference in the case of CD69+CD8+ T cells. Conclusions: CD69+iNKT may be a biomarker to assess liver fibrosis progression in NAFLD. CD69+CD8+ T cells were identified as a potential distinctive biomarker for distinguishing DILI from NAFLD. | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III PI18/01804 PI19/00883 PI21/01248 | es_ES |
dc.description.sponsorship | Junta de Andalucia UMA18-FEDERJA-194 PI18-RT-3364 PI-0285-2016 | es_ES |
dc.description.sponsorship | FEDER funds ("A way to make Europe") ("Andalucia se mueve con Europa") | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Non-alcoholic fatty liver disease (NAFLD) | es_ES |
dc.subject | Drug-induced liver injury (DILI) | es_ES |
dc.subject | Immunophenotype | es_ES |
dc.subject | Immune response | es_ES |
dc.subject | Liver fibrosis | es_ES |
dc.title | Differential iNKT and T Cells Activation in Non-Alcoholic Fatty Liver Disease and Drug-Induced Liver Injury | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/biomedicines10010055 | |
dc.type.hasVersion | VoR | es_ES |