Cortical monitoring of cardiac activity during rapid eye movement sleep: the heartbeat evoked potential in phasic and tonic rapid-eye-movement microstates
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Oxford University Press
Heartbeat evoked potentialSleepREMInteroceptionMicrostates
Péter Simor... [et al.]. Cortical monitoring of cardiac activity during rapid eye movement sleep: the heartbeat evoked potential in phasic and tonic rapid-eye-movement microstates, Sleep, Volume 44, Issue 9, September 2021, zsab100, [https://doi.org/10.1093/sleep/zsab100]
SponsorshipHungarian Scientific Research Fund (NKFI FK 128100 and K 128117); Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary; European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska–Curie grant (agreement No. 801505); Spanish Ministry of Science, Innovation and Universities (PGC2018-096655-A-I00); ELTE Thematic Excellence Programme 2020 TKP2020-IKA-05 National Research, Development and Innovation Office
Sleep is a fundamental physiological state that facilitates neural recovery during periods of attenuated sensory processing. On the other hand, mammalian sleep is also characterized by the interplay between periods of increased sleep depth and environmental alertness. Whereas the heterogeneity of microstates during non-rapid-eye-movement (NREM) sleep was extensively studied in the last decades, transient microstates during rapid-eye-movement (REM) sleep received less attention. REM sleep features two distinct microstates: phasic and tonic. Previous studies indicate that sensory processing is largely diminished during phasic REM periods, whereas environmental alertness is partially reinstated when the brain switches into tonic REM sleep. Here, we investigated interoceptive processing as quantified by the heartbeat evoked potential (HEP) during REM microstates. We contrasted the HEPs of phasic and tonic REM periods using two separate databases that included the nighttime polysomnographic recordings of healthy young individuals (N = 20 and N = 19). We find a differential HEP modulation of a late HEP component (after 500 ms post-R-peak) between tonic and phasic REM. Moreover, the late tonic HEP component resembled the HEP found in resting wakefulness. Our results indicate that interoception with respect to cardiac signals is not uniform across REM microstates, and suggest that interoceptive processing is partially reinstated during tonic REM periods. The analyses of the HEP during REM sleep may shed new light on the organization and putative function of REM microstates.