@misc{10481/73119,
year = {2021},
month = {4},
url = {http://hdl.handle.net/10481/73119},
abstract = {Sleep is a fundamental physiological state that facilitates neural recovery during periods of attenuated sensory processing. On the other
hand, mammalian sleep is also characterized by the interplay between periods of increased sleep depth and environmental alertness.
Whereas the heterogeneity of microstates during non-rapid-eye-movement (NREM) sleep was extensively studied in the last decades,
transient microstates during rapid-eye-movement (REM) sleep received less attention. REM sleep features two distinct microstates: phasic
and tonic. Previous studies indicate that sensory processing is largely diminished during phasic REM periods, whereas environmental
alertness is partially reinstated when the brain switches into tonic REM sleep. Here, we investigated interoceptive processing as quantified
by the heartbeat evoked potential (HEP) during REM microstates. We contrasted the HEPs of phasic and tonic REM periods using two separate
databases that included the nighttime polysomnographic recordings of healthy young individuals (N = 20 and N = 19). We find a differential
HEP modulation of a late HEP component (after 500 ms post-R-peak) between tonic and phasic REM. Moreover, the late tonic HEP component
resembled the HEP found in resting wakefulness. Our results indicate that interoception with respect to cardiac signals is not uniform across
REM microstates, and suggest that interoceptive processing is partially reinstated during tonic REM periods. The analyses of the HEP during
REM sleep may shed new light on the organization and putative function of REM microstates.},
organization = {Hungarian Scientific Research
Fund (NKFI FK 128100 and K
128117)},
organization = {Higher
Education Institutional Excellence Program of the Ministry of
Human Capacities in Hungary},
organization = {European Union’s
Horizon 2020 Research and Innovation Programme under the
Marie Sklodowska–Curie grant (agreement No. 801505)},
organization = {Spanish Ministry of Science,
Innovation and Universities (PGC2018-096655-A-I00)},
organization = {ELTE Thematic Excellence Programme 2020
TKP2020-IKA-05 National Research, Development
and Innovation Office},
publisher = {Oxford University Press},
keywords = {Heartbeat evoked potential},
keywords = {Sleep},
keywords = {REM},
keywords = {Interoception},
keywords = {Microstates},
title = {Cortical monitoring of cardiac activity during rapid eye movement sleep: the heartbeat evoked potential in phasic and tonic rapid-eye-movement microstates},
doi = {10.1093/sleep/zsab100},
author = {Simor, Péter and Perakakis, Pandelis},
}