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dc.contributor.authorOngaro, Linda
dc.contributor.authorAlarcón Riquelme, Marta Eugenia
dc.identifier.citationOngaro, L... [et al.]. Evaluating the Impact of Sex-Biased Genetic Admixture in the Americas through the Analysis of Haplotype Data. Genes 2021, 12, 1580. []es_ES
dc.descriptionThis work was supported by the European Union through the European Regional Development Fund (Project No. 2014-2020.4.01.16-0030 to LO, LM, MM, FM; Project No. 2014-2020.4.01.16-0271 to RF; Project No. 2014-2020.4.01.16-0125 to RF; Project No. 2014-2020.4.01.16-0024 to LM, DM, LP; Project No. 2014-2020.4.01.15-0012 to MM; Project no. MOBEC008 to MM). This work was supported by the Estonian Research Council grant PUT (PRG243) to RF and MM and PUT (PRG1027) to KT. This research was supported by the European Union through Horizon 2020 research and innovation programme under grant no 810645 to MM and no 824110 to KT. AA and MRC received support from the Italian Ministry of Education, University and Research (MIUR) for Progetti PRIN2017 20174BTC4R and the Dipartimenti di Eccellenza Program (2018-2022).es_ES
dc.description.abstractA general imbalance in the proportion of disembarked males and females in the Americas has been documented during the Trans-Atlantic Slave Trade and the Colonial Era and, although less prominent, more recently. This imbalance may have left a signature on the genomes of modern-day populations characterised by high levels of admixture. The analysis of the uniparental systems and the evaluation of continental proportion ratio of autosomal and X chromosomes revealed a general sex imbalance towards males for European and females for African and Indigenous American ancestries. However, the consistency and degree of this imbalance are variable, suggesting that other factors, such as cultural and social practices, may have played a role in shaping it. Moreover, very few investigations have evaluated the sex imbalance using haplotype data, containing more critical information than genotypes. Here, we analysed genome-wide data for more than 5000 admixed American individuals to assess the presence, direction and magnitude of sex-biased admixture in the Americas. For this purpose, we applied two haplotype-based approaches, ELAI and NNLS, and we compared them with a genotype-based method, ADMIXTURE. In doing so, besides a general agreement between methods, we unravelled that the post-colonial admixture dynamics show higher complexity than previously described.es_ES
dc.description.sponsorshipEuropean Commission 2014-2020.4.01.16-0030 2014-2020.4.01.16-0271 2014-2020.4.01.16-0125 2014-2020.4.01.16-0024 2014-2020.4.01.15-0012es_ES
dc.description.sponsorshipEstonian Research Council grant PUT PRG243 PRG1027es_ES
dc.description.sponsorshipEuropean Commission 810645 824110es_ES
dc.description.sponsorshipMinistry of Education, Universities and Research (MIUR) PRIN2017 20174BTC4Res_ES
dc.rightsAtribución 3.0 España*
dc.subjectAmerican populationses_ES
dc.subjectSex-biased imbalancees_ES
dc.subjectHuman migrationses_ES
dc.titleEvaluating the Impact of Sex-Biased Genetic Admixture in the Americas through the Analysis of Haplotype Dataes_ES

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