dc.contributor.author | Lozano, Manuel | |
dc.contributor.author | Gil Hernández, Fernando | |
dc.contributor.author | Olmedo Palma, Pablo | |
dc.date.accessioned | 2021-10-28T06:44:11Z | |
dc.date.available | 2021-10-28T06:44:11Z | |
dc.date.issued | 2021-08-06 | |
dc.identifier.citation | Manuel Lozano... [et al.]. Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors, Chemosphere, Volume 286, Part 2, 2022, 131809, ISSN 0045-6535, [https://doi.org/10.1016/j.chemosphere.2021.131809] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/71145 | |
dc.description | This study was funded by Grants from EU (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1); Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02187, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/01142 and PI19/1338; Miguel Servet FEDER MS15/00025, MS20/0006, CPII16/00051, and FIS-FSE: 17/00260); CIBERESP; Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), AICO/2020/285, and Alicia Koplowitz Foundation 2017; Generalitat de Catalunya-CIRIT 1999SGR 00241; Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065); Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221).
We acknowledge support from the Spanish Ministry of Science, Innovation and Universities through the "Centro de Excelencia Severo Ochoa 2019-2023" Programme (CEX2018000806-S), and from the Generalitat de Catalunya through the CERCA Programme, as well as the municipalities in the study area. | es_ES |
dc.description.abstract | Background: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic
materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus.
Objectives: To describe the prenatal concentrations of metals and metalloids and to study the associated sociodemographic,
environmental and dietary factors in pregnant Spanish women.
Methods: Subjects were 1346 pregnant women of the INMA Project, for whom the following metals arsenic (As),
cadmium (Cd), cobalt (Co), copper (Cu), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se),
thallium (Tl) and zinc (Zn) were determined in urine, at both the first and the third trimesters of gestation.
Sociodemographic, dietary and environmental information was collected through questionnaires during pregnancy.
Multiple linear mixed models were built in order to study the association between each metal and
metalloid concentrations and the sociodemographic, environmental and dietary factors.
Results: The most detected compounds were As, Co, Mo, Sb, Se and Zn at both trimesters. Zn was the element
found in the highest concentrations at both trimesters and Tl was detected in the lowest concentrations. We
observed significant associations between As, Cd, Cu, Sb, Tl and Zn concentrations and working situation, social
class and age. Seafood, meat, fruits, nuts, vegetables and alcohol intake affected the levels of all the metals but Cd
and Cu. Proximity to industrial areas, fields and air pollution were related to all metals except Cd, Sb and Se. Conclusions: This is the first large prospective longitudinal study on the exposure to metals and metalloids during
pregnancy and associated factors to include several cohorts in Spain. The present study shows that some
modifiable lifestyles, food intakes and environmental factors could be associated with prenatal exposure to metal
(loid)s, which may be considered in further studies to assess their relationship with neonatal health outcomes. | es_ES |
dc.description.sponsorship | European Commission 282957
HEALTH.2010.2.4.5-1 | es_ES |
dc.description.sponsorship | Spain: ISCIII Red INMA G03/176
CB06/02/0041
CIBERESP | es_ES |
dc.description.sponsorship | Generalitat Valenciana: FISABIO UGP 15-230
UGP-15-244
UGP-15-249
AICO/2020/285 | es_ES |
dc.description.sponsorship | Alicia Koplowitz Foundation | es_ES |
dc.description.sponsorship | Generalitat de Catalunya | es_ES |
dc.description.sponsorship | General Electric CIRIT 1999SGR 00241 | es_ES |
dc.description.sponsorship | Department of Health of the Basque Government 2005111093
2009111069
2013111089
2015111065 | es_ES |
dc.description.sponsorship | Provincial Government of Gipuzkoa DFG06/002
DFG08/001
DFG15/221 | es_ES |
dc.description.sponsorship | Spanish Ministry of Science, Innovation and Universities CEX2018000806-S | es_ES |
dc.description.sponsorship | Generalitat de Catalunya | es_ES |
dc.description.sponsorship | General Electric | es_ES |
dc.description.sponsorship | Spain (FIS-FEDER) PI03/1615
PI04/1509
PI04/1112
PI04/1931
PI05/1079
PI05/1052
PI06/0867
PI06/1213
PI07/0314
PI09/00090
PI09/02647
PI11/01007
PI11/02591
PI11/02038
PI13/1944
PI13/2032
PI13/02187 | es_ES |
dc.description.sponsorship | Spain (Miguel Servet FEDER) MS15/00025
MS20/0006
CPII16/00051 | es_ES |
dc.description.sponsorship | Spain (FIS-FSE) 17/00260 | es_ES |
dc.description.sponsorship | the Spain (FIS-FEDER) PI14/00891
PI14/01687
PI16/1288
PI17/00663
PI18/01142
PI19/1338 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Metals | es_ES |
dc.subject | Metalloids | es_ES |
dc.subject | Prenatal exposure | es_ES |
dc.subject | Environmental exposure | es_ES |
dc.subject | Diet | es_ES |
dc.title | Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors | es_ES |
dc.type | journal article | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/282957 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1016/j.chemosphere.2021.131809 | |
dc.type.hasVersion | VoR | es_ES |