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dc.contributor.authorOsuna Prieto, Francisco Javier 
dc.contributor.authorMartínez Téllez, Borja Manuel 
dc.contributor.authorOrtiz-Alvarez, Lourdes
dc.contributor.authorJurado Fasoli, Lucas 
dc.contributor.authorXu, Huiwen 
dc.contributor.authorRuiz Ruiz, Jonatan
dc.description.abstractBackground: Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for infammatory and metabolic disorders in middle-aged adults. The relationship between plasma succinate levels and cardiovascular disease (CVD) risk in young adults is unknown. Methods: Cross-sectional study in 100 (65% women) individuals aged 18–25 years from the ACTIvating Brown Adipose Tissue through Exercise (ACTIBATE) study cohort. CVD risk factors, body composition, dietary intake, basal metabolic rate, and cardiorespiratory ftness were assessed by routine methods. Plasma succinate was measured with an enzyme-based assay. Brown adipose tissue (BAT) was evaluated by positron emission tomography, and circulating oxylipins were assessed by targeted metabolomics. Fecal microbiota composition was analyzed in a sub-sample. Results: Individuals with higher succinate levels had higher levels of visceral adipose tissue (VAT) mass (+42.5%), tri‑ glycerides (+63.9%), C-reactive protein (+124.2%), diastolic blood pressure (+5.5%), and pro-infammatory omega-6 oxylipins than individuals with lower succinate levels. Succinate levels were also higher in metabolically unhealthy individuals than in healthy overweight/obese peers. Succinate levels were not associated with BAT volume or activity or with fecal microbiota composition and diversity. Conclusions: Plasma succinate levels are linked to a specifc pro-infammatory omega-6 signature pattern and higher VAT levels, and seem to refect the cardiovascular status of young adults.es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016-79512-R to JRR and RTI2018-093919-B to SFV)es_ES
dc.description.sponsorshipEuropean Regional Development Funds (ERDF)es_ES
dc.description.sponsorshipSpanish Ministry of Education (FPU16/02828, FPU16/05159, FPU17/01523 and FPU19/01609)es_ES
dc.description.sponsorshipUniversity of Granada Plan Propio de Investigación 2016-Excellence actions–Unit of Excellence on Exercise and Health (UCEES)es_ES
dc.description.sponsorshipJunta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF: ref. SOMM17/6107/UGR)es_ES
dc.description.sponsorshipThe Spanish Ministry of Science and Innovation (PI20/00095 to VCM and PI20/00338 to JV) co-fnanced by the European Regional Development Fund (ERDF)es_ES
dc.description.sponsorshipRamón y Cajal program (RYC2019026490-I) from the Spanish Ministry of Science and Innovation, co-fnanced by the ERDFes_ES
dc.description.sponsorshipy Fundación Bancaria Caixa d’Estalvis i Pensions de Barcelona (HR20-00051 to S.F.-V.)es_ES
dc.description.sponsorshipThe Netherlands CardioVascular Research Initiative: ‘the Dutch Heart Foundation, Dutch Federation of University Medical Centers, The Netherlands Organization for Health Research and Development and the Royal Netherlands Academy of Sciences’ (CVON2017-20 GENIUS-2) to PCNRes_ES
dc.description.sponsorshipChinese Scholarship Council (CSC, No. 201707060012) to XDes_ES
dc.description.sponsorshipMiguel Servet tenure-track program (CP10/00438 and CPII16/00008) from the Fondo de Investigación Sanitaria, co-fnanced by the ERDFes_ES
dc.description.sponsorshipFundación Alfonso Martin Escuderoes_ES
dc.rightsAtribución 3.0 España*
dc.subjectObesity es_ES
dc.subjectVisceral adiposityes_ES
dc.titleElevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adultses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España