Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults
Metadatos
Mostrar el registro completo del ítemAutor
Osuna Prieto, Francisco Javier; Martínez Téllez, Borja Manuel; Ortiz-Alvarez, Lourdes; Jurado Fasoli, Lucas; Xu, Huiwen; Ruiz Ruiz, JonatanEditorial
BMC
Materia
Obesity Visceral adiposity Infammation Oxylipins Succinate
Fecha
2021Referencia bibliográfica
https://doi.org/10.1186/s12933-021-01333-3
Patrocinador
Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad (DEP2016-79512-R to JRR and RTI2018-093919-B to SFV); European Regional Development Funds (ERDF); Spanish Ministry of Education (FPU16/02828, FPU16/05159, FPU17/01523 and FPU19/01609); University of Granada Plan Propio de Investigación 2016-Excellence actions–Unit of Excellence on Exercise and Health (UCEES); Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF: ref. SOMM17/6107/UGR); The Spanish Ministry of Science and Innovation (PI20/00095 to VCM and PI20/00338 to JV) co-fnanced by the European Regional Development Fund (ERDF); Ramón y Cajal program (RYC2019026490-I) from the Spanish Ministry of Science and Innovation, co-fnanced by the ERDF; y Fundación Bancaria Caixa d’Estalvis i Pensions de Barcelona (HR20-00051 to S.F.-V.); The Netherlands CardioVascular Research Initiative: ‘the Dutch Heart Foundation, Dutch Federation of University Medical Centers, The Netherlands Organization for Health Research and Development and the Royal Netherlands Academy of Sciences’ (CVON2017-20 GENIUS-2) to PCNR; Chinese Scholarship Council (CSC, No. 201707060012) to XD; Miguel Servet tenure-track program (CP10/00438 and CPII16/00008) from the Fondo de Investigación Sanitaria, co-fnanced by the ERDF; Fundación Alfonso Martin EscuderoResumen
Background: Succinate is produced by both host and microbiota, with a key role in the interplay of immunity and
metabolism and an emerging role as a biomarker for infammatory and metabolic disorders in middle-aged adults.
The relationship between plasma succinate levels and cardiovascular disease (CVD) risk in young adults is unknown.
Methods: Cross-sectional study in 100 (65% women) individuals aged 18–25 years from the ACTIvating Brown
Adipose Tissue through Exercise (ACTIBATE) study cohort. CVD risk factors, body composition, dietary intake, basal
metabolic rate, and cardiorespiratory ftness were assessed by routine methods. Plasma succinate was measured with
an enzyme-based assay. Brown adipose tissue (BAT) was evaluated by positron emission tomography, and circulating
oxylipins were assessed by targeted metabolomics. Fecal microbiota composition was analyzed in a sub-sample.
Results: Individuals with higher succinate levels had higher levels of visceral adipose tissue (VAT) mass (+42.5%), tri‑
glycerides (+63.9%), C-reactive protein (+124.2%), diastolic blood pressure (+5.5%), and pro-infammatory omega-6
oxylipins than individuals with lower succinate levels. Succinate levels were also higher in metabolically unhealthy
individuals than in healthy overweight/obese peers. Succinate levels were not associated with BAT volume or activity
or with fecal microbiota composition and diversity.
Conclusions: Plasma succinate levels are linked to a specifc pro-infammatory omega-6 signature pattern and
higher VAT levels, and seem to refect the cardiovascular status of young adults.