Zn-Containing Membranes for Guided Bone Regeneration in Dentistry
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Toledano Pérez, Manuel; Vallecillo Rivas, Marta; Osorio, María T.; Muñoz Soto, Esther; Toledano Osorio, Manuel; Vallecillo, Cristina; Toledano, Raquel; Osorio Ruiz, RaquelEditorial
MDPI
Materia
Zinc Membranes Bioactivity Guided bone regeneration Mechanical Microscopy Antibacterial Cytotoxicity
Date
2021-05-29Referencia bibliográfica
Toledano, M... [et al.]. Zn-Containing Membranes for Guided Bone Regeneration in Dentistry. Polymers 2021, 13, 1797. [https://doi.org/10.3390/polym13111797]
Sponsorship
University of Granada/Regional Government of Andalusia Research Fund from Spain; European Commission A-BIO-157-UGR-18/FEDERAbstract
Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone
in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in
bone healing and regeneration is necessary. The aim of the present study is to state the effect of
doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A
literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI,
Embase, Scopus andWeb of Science. A narrative exploratory review was undertaken, focusing on the
antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity,
bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these
membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial
colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to
be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility,
strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the
highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis,
angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with
SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase
and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted
pro-healing phenotypes.