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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/69476">
      <dc:title>Zn-Containing Membranes for Guided Bone Regeneration in Dentistry</dc:title>
      <dc:creator>Toledano Pérez, Manuel</dc:creator>
      <dc:creator>Vallecillo Rivas, Marta</dc:creator>
      <dc:creator>Osorio, María T.</dc:creator>
      <dc:creator>Muñoz Soto, Esther</dc:creator>
      <dc:creator>Toledano Osorio, Manuel</dc:creator>
      <dc:creator>Vallecillo, Cristina</dc:creator>
      <dc:creator>Toledano, Raquel</dc:creator>
      <dc:creator>Osorio Ruiz, Raquel</dc:creator>
      <dc:subject>Zinc</dc:subject>
      <dc:subject>Membranes</dc:subject>
      <dc:subject>Bioactivity</dc:subject>
      <dc:subject>Guided bone regeneration</dc:subject>
      <dc:subject>Mechanical</dc:subject>
      <dc:subject>Microscopy</dc:subject>
      <dc:subject>Antibacterial</dc:subject>
      <dc:subject>Cytotoxicity</dc:subject>
      <dc:description>This work was funded by the University of Granada/Regional Government of Andalusia Research Fund from Spain and European Regional Development Fund (A-BIO-157-UGR-18/FEDER).</dc:description>
      <dc:description>Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone&#xd;
in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in&#xd;
bone healing and regeneration is necessary. The aim of the present study is to state the effect of&#xd;
doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A&#xd;
literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI,&#xd;
Embase, Scopus andWeb of Science. A narrative exploratory review was undertaken, focusing on the&#xd;
antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity,&#xd;
bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these&#xd;
membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial&#xd;
colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to&#xd;
be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility,&#xd;
strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the&#xd;
highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis,&#xd;
angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with&#xd;
SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase&#xd;
and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted&#xd;
pro-healing phenotypes.</dc:description>
      <dc:date>2021-07-02T11:10:44Z</dc:date>
      <dc:date>2021-07-02T11:10:44Z</dc:date>
      <dc:date>2021-05-29</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Toledano, M... [et al.]. Zn-Containing Membranes for Guided Bone Regeneration in Dentistry. Polymers 2021, 13, 1797. [https://doi.org/10.3390/polym13111797]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/69476</dc:identifier>
      <dc:identifier>10.3390/polym13111797</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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