Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572
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AuthorDíez Echave, Patricia; Garrido-Mesa, José; Vezza, Teresa; Hidalgo García, Laura; Algieri, Francesca; Rodríguez Nogales, Alba; Rodríguez Cabezas, María Elena; Gálvez Peralta, Julio Juan
Limosilactobacillus reuteriProbioticsColonic modelDSS-induced colitic modelImmunomodulationReuterinProtective effect
Diez-Echave, P.; Martín-Cabrejas, I.; Garrido-Mesa, J.; Langa, S.; Vezza, T.; Landete, J.M.; Hidalgo-García, L.; Algieri, F.; Mayer, M.J.; Narbad, A.; et al. Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572. Nutrients 2021, 13, 1860. https:// doi.org/10.3390/nu13061860
Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.