dc.contributor.author | Sánchez Hernández, Silvia | |
dc.contributor.author | Olalla Herrera, Manuel | |
dc.date.accessioned | 2021-05-21T10:05:38Z | |
dc.date.available | 2021-05-21T10:05:38Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Sánchez-Hernández, S.; Théron, L.; Jiménez-Barrios, P.; Olalla-Herrera, M.; Recio, I.; Miralles, B. Protein Profile and Simulated Digestive Behavior of Breast Milk from Overweight and Normal Weight Mothers. Foods 2021, 10, 887. https:// doi.org/10.3390/foods10040887 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/68615 | |
dc.description.abstract | Human milk proteins have shown to vary in concentration and distribution through
lactation. However, while some regulatory components, such as hormones, have shown associations
with regard to the mothers’ body mass index, there is limited information on the possible influence
of this condition on the whole protein distribution. The objective of this study was to evaluate the
protein profile of human milk from normal weight and overweight or obese mothers to identify
differences in protein expression in colostrum, transitional and mature milk. The mass spectrometry
analysis showed the ability to class with a high degree of confidence the lactation state and the milk
profile according to the mother’s condition. Individual milk samples were subjected to a digestion
in vitro model that takes into account the specificities of the gastrointestinal conditions of full-term
newborn infants. The digestion products were compared with available data from the digestive
contents in newborns. The behavior of the most abundant proteins and the overall peptide generation
and survival, showed good correspondence with in vivo data. | es_ES |
dc.description.sponsorship | PID2019-107663RB-I00 from Ministry of Science and
Innovation (MICINN) | es_ES |
dc.description.sponsorship | FPU grant (FPU15-04549) from the Spanish Ministry
of Education, Culture and Sports | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Human milk | es_ES |
dc.subject | MALDI mass spectrometry | es_ES |
dc.subject | Body mass index | es_ES |
dc.subject | In vitro infant digestion | es_ES |
dc.subject | Bioactive proteins | es_ES |
dc.title | Protein Profile and Simulated Digestive Behavior of Breast Milk from Overweight and Normal Weight Mothers | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/foods10040887 | |