Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights
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AuthorRodríguez Sojo, María Jesús; Ruiz Malagón, Antonio Jesús; Rodríguez Cabezas, María Elena; Gálvez Peralta, Julio Juan; Rodríguez Nogales, Alba
ProbioticLimosilactobacillus fermentum CECT5716ImmunomodulationDysbiosisMechanism of actionGastrointestinal diseasesMicrobiota
Rodríguez-Sojo, M.J.; Ruiz-Malagón, A.J.; Rodríguez-Cabezas, M.E.; Gálvez, J.; Rodríguez-Nogales, A. Limosilactobacillus fermentum CECT5716: Mechanisms and Therapeutic Insights. Nutrients 2021, 13, 1016. [https://doi.org/10.3390/nu13031016]
SponsorshipJunta de Andalucia CTS 164; Instituto de Salud Carlos III European Commission PI19/01058; European Commission
Probiotics microorganisms exert their health-associated activities through some of the following general actions: competitive exclusion, enhancement of intestinal barrier function, production of bacteriocins, improvement of altered microbiota, and modulation of the immune response. Among them, Limosilactobacillus fermentum CECT5716 has become one of the most promising probiotics and it has been described to possess potential beneficial effects on inflammatory processes and immunological alterations. Different studies, preclinical and clinical trials, have evidenced its anti-inflammatory and immunomodulatory properties and elucidated the precise mechanisms of action involved in its beneficial effects. Therefore, the aim of this review is to provide an updated overview of the effect on host health, mechanisms, and future therapeutic approaches.