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dc.contributor.authorGu, Shoujun
dc.contributor.authorLópez Escámez, José Antonio
dc.identifier.citationGu S, Olszewski R, Nelson L, Gallego-Martinez A, Lopez-Escamez JA and Hoa M (2021) Identification of Potential Meniere’s Disease Targets in the Adult Stria Vascularis. Front. Neurol. 12:630561. [doi: 10.3389/fneur.2021.630561]es_ES
dc.description.abstractThe stria vascularis generates the endocochlear potential and is involved in processes that underlie ionic homeostasis in the cochlear endolymph, both which play essential roles in hearing. The histological hallmark of Meniere’s disease (MD) is endolymphatic hydrops, which refers to the bulging or expansion of the scala media, which is the endolymph-containing compartment of the cochlea. This histologic hallmark suggests that processes that disrupt ion homeostasis or potentially endocochlear potential may underlie MD. While treatments exist for vestibular symptoms related to MD, effective therapies for hearing fluctuation and hearing loss seen in MD remain elusive. Understanding the potential cell types involved in MD may inform the creation of disease mouse models and provide insight into underlying mechanisms and potential therapeutic targets. For these reasons, we compare published datasets related to MD in humans with our previously published adult mouse stria vascularis single-cell and single-nucleus RNA-Seq datasets to implicate potentially involved stria vascularis (SV) cell types in MD. Finally, we provide support for these implicated cell types by demonstrating co-expression of select candidate genes for MD within SV cell types.es_ES
dc.description.sponsorshipIntramural Research Program of the NIH, NIDCD DC000088es_ES
dc.description.sponsorshipEuropean Commission PI17-1644es_ES
dc.description.sponsorshipFIBAO PE-0356-2018es_ES
dc.publisherFrontiers Media SAes_ES
dc.rightsAtribución 3.0 España*
dc.subjectStria vascularises_ES
dc.subjectIon homeostasises_ES
dc.titleIdentification of Potential Meniere’s Disease Targets in the Adult Stria Vascularises_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España