Identification of Potential Meniere’s Disease Targets in the Adult Stria Vascularis
Metadatos
Mostrar el registro completo del ítemEditorial
Frontiers Media SA
Materia
Stria vascularis Single-cell Nucleus RNA-Seq Meniere’s Ion homeostasis
Fecha
2021-02-05Referencia bibliográfica
Gu S, Olszewski R, Nelson L, Gallego-Martinez A, Lopez-Escamez JA and Hoa M (2021) Identification of Potential Meniere’s Disease Targets in the Adult Stria Vascularis. Front. Neurol. 12:630561. [doi: 10.3389/fneur.2021.630561]
Patrocinador
Intramural Research Program of the NIH, NIDCD DC000088; European Commission PI17-1644; FIBAO PE-0356-2018Resumen
The stria vascularis generates the endocochlear potential and is involved in processes
that underlie ionic homeostasis in the cochlear endolymph, both which play essential
roles in hearing. The histological hallmark of Meniere’s disease (MD) is endolymphatic
hydrops, which refers to the bulging or expansion of the scala media, which is the
endolymph-containing compartment of the cochlea. This histologic hallmark suggests
that processes that disrupt ion homeostasis or potentially endocochlear potential
may underlie MD. While treatments exist for vestibular symptoms related to MD,
effective therapies for hearing fluctuation and hearing loss seen in MD remain elusive.
Understanding the potential cell types involved in MD may inform the creation of
disease mouse models and provide insight into underlying mechanisms and potential
therapeutic targets. For these reasons, we compare published datasets related to MD
in humans with our previously published adult mouse stria vascularis single-cell and
single-nucleus RNA-Seq datasets to implicate potentially involved stria vascularis (SV) cell
types in MD. Finally, we provide support for these implicated cell types by demonstrating
co-expression of select candidate genes for MD within SV cell types.