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dc.contributor.authorJurado, Rocío
dc.contributor.authorGálvez Rodríguez, Natividad
dc.identifier.citationJurado, R.; Gálvez, N. Apoferritin Amyloid-Fibril Directed the In Situ Assembly and/or Synthesis of Optical and Magnetic Nanoparticles. Nanomaterials 2021, 11, 146. []es_ES
dc.description.abstractThe coupling of proteins that can assemble, recognise or mineralise specific inorganic species is a promising strategy for the synthesis of nanoscale materials with a controllable morphology and functionality. Herein, we report that apoferritin protein amyloid fibrils (APO) have the ability to assemble and/or synthesise various metal and metal compound nanoparticles (NPs). As such, we prepared metal NP–protein hybrid bioconjugates with improved optical and magnetic properties by coupling diverse gold (AuNPs) and magnetic iron oxide nanoparticles (MNPs) to apoferritin amyloid fibrils and compared them to the well-known -lactoglobulin (BLG) protein. In a second approach, we used of solvent-exposed metal-binding residues in APO amyloid fibrils as nanoreactors for the in situ synthesis of gold, silver (AgNPs) and palladium nanoparticles (PdNPs). Our results demonstrate, the versatile nature of the APO biotemplate and its high potential for preparing functional hybrid bionanomaterials. Specifically, the use of apoferritin fibrils as vectors to integrate magnetic MNPs or AuNPs is a promising synthetic strategy for the preparation of specific contrast agents for early in vivo detection using various bioimaging techniques.es_ES
dc.description.sponsorshipJunta de Andalucía P18-FQM-1373es_ES
dc.description.sponsorshipMINECO Project PID2019-111461GB-100es_ES
dc.rightsAtribución 3.0 España*
dc.subjectAmyloid fibrilses_ES
dc.subjectApoferritin proteines_ES
dc.subjectB -lactoglobulines_ES
dc.subjectMagnetic nanoparticlees_ES
dc.subjectGold nanoparticleses_ES
dc.subjectMRI and optical imaginges_ES
dc.titleApoferritin Amyloid-Fibril Directed the In Situ Assembly and/or Synthesis of Optical and Magnetic Nanoparticleses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España