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dc.contributor.authorCampoy Folgoso, Cristina 
dc.contributor.authorAzaryah, Hatim
dc.contributor.authorTorres Espínola, Francisco J.
dc.contributor.authorMartínez Zaldívar, Cristina
dc.contributor.authorGarcía Santos, José Antonio 
dc.contributor.authorDemmelmair, Hans
dc.contributor.authorRamírez Tortosa, María Carmen 
dc.contributor.authorReischl, Eva
dc.contributor.authorLuna Del Castillo, Juan De Dios 
dc.contributor.authorPérez García, Miguel 
dc.date.accessioned2021-03-08T12:39:33Z
dc.date.available2021-03-08T12:39:33Z
dc.date.issued2020-12-31
dc.identifier.citationCampoy, C.; Azaryah, H.; Torres-Espínola, F.J.; Martínez-Zaldívar, C.; García-Santos, J.A.; Demmelmair, H.; Haile, G.; Györei, E.; Ramírez-Tortosa, M.d.C.; Reischl, E.; et al. Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms Are Associated with Children’s Processing Speed up to Age 9 Years. Nutrients 2021, 13, 131. [https://doi.org/10.3390/nu13010131]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/66988
dc.description.abstractBoth pre- and early postnatal supplementation with docosahexaenoic acid (DHA), arachidonic acid (AA) and folate have been related to neural development, but their long-term effects on later neural function remain unclear. We evaluated the long-term effects of maternal prenatal supplementation with fish-oil (FO), 5-methyltetrahydrofolate (5-MTHF), placebo or FO + 5-MTHF, as well as the role of fatty acid desaturase (FADS) gene cluster polymorphisms, on their offspring’s processing speed at later school age. This study was conducted in NUHEAL children at 7.5 (n = 143) and 9 years of age (n = 127). Processing speed tasks were assessed using Symbol Digit Modalities Test (SDMT), Children Color Trails Test (CCTT) and Stroop Color andWord Test (SCWT). Long-chain polyunsaturated fatty acids, folate and total homocysteine (tHcy) levels were determined at delivery from maternal and cord blood samples. FADS and methylenetetrahydrofolate reductase (MTHFR) 677 C > T genetic polymorphisms were analyzed. Mixed models (linear and logistic) were performed. There were significant differences in processing speed performance among children at different ages (p < 0.001). The type of prenatal supplementation had no effect on processing speed in children up to 9 years. Secondary exploratory analyses indicated that children born to mothers with higher AA/DHA ratio at delivery (p < 0.001) and heterozygotes for FADS1 rs174556 (p < 0.05) showed better performance in processing speed at 9 years. Negative associations between processing speed scores and maternal tHcy levels at delivery were found. Our findings suggest speed processing development in children up to 9 years could be related to maternal factors, including AA/DHA and tHcy levels, and their genetic background, mainly FADS polymorphism. These considerations support that maternal prenatal supplementation should be quantitatively adequate and individualized to obtain better brain development and mental performance in the offspring.es_ES
dc.description.sponsorshipEuropean Commission 212652 007036 QLK1-CT-1999-00888es_ES
dc.description.sponsorshipEuropean Commission European Commission Joint Research Centre DYNAHEALTH-633595 Lifecycle-733206es_ES
dc.description.sponsorshipEuropean Research Council Advanced Grant META-GROWTH ERC-2012AdG 322605es_ES
dc.description.sponsorshipErasmus Plus Programme Early Nutrition eAcademy Southeast Asia 573651EPP-1-2016-1-DE-EPPKA2-CBHE-JPes_ES
dc.description.sponsorshipErasmus Plus Programme Capacity Building to Improve Early Nutrition and Health in South Africa 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JPes_ES
dc.description.sponsorshipEU Interreg Programme Focus in CD-CE111es_ES
dc.description.sponsorshipEuropean Joint Programming Initiative Project NutriPROGRAM and EndObesityes_ES
dc.description.sponsorshipGerman Ministry of Education and Research, Berlin 01 GI 0825es_ES
dc.description.sponsorshipGerman Research Foundation (DFG) Ko912/12-1 INST 409/224-1 FUGGes_ES
dc.description.sponsorshipElse Kroner-Fresenius-Foundationes_ES
dc.description.sponsorshipLMU University Hospitalses_ES
dc.language.isoenges_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectLong chain polyunsaturated fatty acidses_ES
dc.subjectFolatees_ES
dc.subjectPrenatal supplementationes_ES
dc.subjectProcessing speedes_ES
dc.subjectNeurodevelopmees_ES
dc.subjectFADS genees_ES
dc.subjectChildrenes_ES
dc.titleLong-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms Are Associated with Children’s Processing Speed up to Age 9 Yearses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu13010131
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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