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dc.contributor.authorCheca Ros, Ana
dc.contributor.authorMolina Carballo, Antonio 
dc.contributor.authorCampoy Folgoso, Cristina 
dc.contributor.authorMuñoz Hoyos, Antonio
dc.identifier.citationCheca-Ros, A.; Jeréz-Calero, A.; Molina-Carballo, A.; Campoy, C.; Muñoz-Hoyos, A. Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications. Nutrients 2021, 13, 249. []es_ES
dc.description.abstractStudies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (CNS), or so-called the microbiome–gut–brain axis (MGBA), is involved in diverse neuropsychiatric diseases in children and adults. In pediatric age, most studies have focused on patients with autism. However, evidence of the role played by the MGBA in attention deficit/hyperactivity disorder (ADHD), the most common neurodevelopmental disorder in childhood, is still scanty and heterogeneous. This review aims to provide the current evidence on the functioning of the MGBA in pediatric patients with ADHD and the specific role of omega-3 polyunsaturated fatty acids (!-3 PUFAs) in this interaction, as well as the potential of the GM as a therapeutic target for ADHD. We will explore: (1) the diverse communication pathways between the GM and the CNS; (2) changes in the GM composition in children and adolescents with ADHD and association with ADHD pathophysiology; (3) influence of the GM on the !-3 PUFA imbalance characteristically found in ADHD; (4) interaction between the GM and circadian rhythm regulation, as sleep disorders are frequently comorbid with ADHD; (5) finally, we will evaluate the most recent studies on the use of probiotics in pediatric patients with ADHD.es_ES
dc.rightsAtribución 3.0 España*
dc.subjectGastrointestinal microbiomees_ES
dc.subjectCircadian rhythms es_ES
dc.subjectFatty acids es_ES
dc.subjectOmega 3es_ES
dc.titleCurrent Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implicationses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España