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dc.contributor.authorMicó-Carnero, Marc
dc.contributor.authorRojano-Alfonso, Carlos
dc.contributor.authorÁlvarez Mercado, Ana Isabel 
dc.contributor.authorGracia-Sancho, Jordi
dc.contributor.authorCasillas-Ramírez, Araní
dc.contributor.authorPeralta, Carmen
dc.identifier.citationMicó-Carnero, M.; Rojano- Alfonso, C.; Álvarez-Mercado, A.I.; Gracia-Sancho, J.; Casillas-Ramírez, A.; Peralta, C. Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery. Int. J. Mol. Sci. 2021, 22, 44. []es_ES
dc.descriptionWe thank Toffa (Language Advisory Service, University of Barcelona, Barcelona, Spain) for revising the English textes_ES
dc.description.abstractMicrobiota is defined as the collection of microorganisms within the gastrointestinal ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An unbalanced microbiota, termed dysbiosis, is related to the development of several liver diseases. The bidirectional relationship between the gut, its microbiota and the liver is referred to as the gut–liver axis. The translocation of bacterial products from the intestine to the liver induces inflammation in different cell types such as Kupffer cells, and a fibrotic response in hepatic stellate cells, resulting in deleterious effects on hepatocytes. Moreover, ischemia-reperfusion injury, a consequence of liver surgery, alters the microbiota profile, affecting inflammation, the immune response and even liver regeneration. Microbiota also seems to play an important role in post-operative outcomes (i.e., liver transplantation or liver resection). Nonetheless, studies to determine changes in the gut microbial populations produced during and after surgery, and affecting liver function and regeneration are scarce. In the present review we analyze and discuss the preclinical and clinical studies reported in the literature focused on the evaluation of alterations in microbiota and its products as well as their effects on post-operative outcomes in hepatic surgery.es_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovacion y Universidades (MCIU) Madrid, Spain RTI2018-095114-B-I00es_ES
dc.description.sponsorshipEuropean Union (Fondos Feder, "Una manera de hacer Europa")es_ES
dc.description.sponsorshipCERCA Program/Generalitat de Catalunyaes_ES
dc.description.sponsorshipSecretaria d'Universitats i Recerca Barcelona, Spain 2017SGR-551es_ES
dc.description.sponsorshipCOST action Programs CA17103 CA17126es_ES
dc.rightsAtribución 3.0 España*
dc.subjectLiver transplantationes_ES
dc.subjectPartial hepatectomyes_ES
dc.subjectLiver surgeryes_ES
dc.titleEffects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgeryes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España