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Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study
dc.contributor.author | Seral Cortes, Miguel | |
dc.contributor.author | Molina Hidalgo, Cristina | |
dc.date.accessioned | 2021-02-10T09:46:01Z | |
dc.date.available | 2021-02-10T09:46:01Z | |
dc.date.issued | 2020-12-16 | |
dc.identifier.citation | Seral-Cortes, M., Sabroso-Lasa, S., Miguel-Etayo, D., Gonzalez-Gross, M., Gesteiro, E., Molina-Hidalgo, C., ... & Labayen, I. (2020). Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study. Nutrients, 12(12), 3841. [doi:10.3390/nu12123841] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/66427 | |
dc.description.abstract | Obesity and metabolic syndrome (MetS) are worldwide major health challenges. The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial e ects may be influenced by genetic variations, modulating the predisposition to obesity or MetS. The aim was to assess whether interaction e ects occur between an obesity genetic risk score (obesity-GRS) and the MD on adiposity and MetS in European adolescents. Multiple linear regression models were used to assess the interaction e ects of an obesity-GRS and the MD on adiposity and MetS and its components. Interaction e ects between theMDon adiposity and MetS were observed in both sex groups (p < 0.05). However, those interaction e ects were only expressed in a certain number of adolescents, when a limited number of risk alleles were present. Regarding adiposity, a total of 51.1% males and 98.7% females had lower body mass index (BMI) as a result of higher MD adherence. Concerning MetS, only 9.9% of males with higher MD adherence had lower MetS scores. However, the same e ect was observed in 95.2% of females. In conclusion, obesity-related genotypes could modulate the relationship between MD adherence and adiposity and MetS in European adolescents; the interaction e ect was higher in females than in males. | es_ES |
dc.description.sponsorship | Iberus Talent Pre-doctoral fellowships 2018, under the European Union's H2020 research and innovation programme under Marie Sklodowska-Curie grant 801586 | es_ES |
dc.description.sponsorship | Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, CIBERObn ISCIII-CB15/00043 | es_ES |
dc.description.sponsorship | European Union (EU) FOOD-CT-2005-007034 | es_ES |
dc.description.sponsorship | HELENA project | es_ES |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness RYC-2010-05957 RYC-2011-09011 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Mdpi | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Metabolic syndrome | es_ES |
dc.subject | Mediterranean diet | es_ES |
dc.subject | Genetic risk score | es_ES |
dc.subject | Helena | es_ES |
dc.subject | Adolescents | es_ES |
dc.subject | Sex | es_ES |
dc.title | Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/nu12123841 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |