Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)
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PERGAMON-ELSEVIER SCIENCE LTD
Colorectal cancerIndustrial pollutionMCC-SpainCase-control studyResidential proximity
García-Pérez, J., de Larrea-Baz, N. F., Lope, V., Molina, A. J., O'Callaghan-Gordo, C., Alonso, M. H., ... & Pollán, M. (2020). Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain). Environment International, 144, doi: 10.1016/j.envint.2020.106055.
SponsorshipScientific Foundation of the Spanish Association Against Cancer (Fundacion Cientifica de la Asociacion Espanola Contra el Cancer (AECC)) EVP-1178/14; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP); Instituto de Salud Carlos III FIS 12/01416; Carlos III Institute of Health (ISCIII) grants; ERDF funds-a way to build Europe PI08/0533 PI08/1359 PI08/1770 PS09/00773Cantabria PS09/01286-Leon PS09/01662-Granada PS09/01903Valencia PS09/02078-Huelva PI11/00226 PI11/01403 PI11/01810 PI11/01889-FEDER PI11/02213 PI12/00150 PI12/00265; Fundacion Caja de Ahorros de Asturias; University of Oviedo; Junta de Castilla y Leon LE22A10-2; Regional Government of the Basque Country; Conselleria de Sanitat of the Generalitat Valenciana AP_061/10; Junta de Andalucia PI-0571-2009 PI-0306-2011 salud201200057018tra; Catalan Government DURSI grant 2014SGR647; European Commission European Commission Joint Research Centre FOOD-CT-2006036224-HIWATE; La Caixa Foundation 2010ACUP 00310; Agency for Management of University and Research Grants (AGAUR) of the Catalan Government 2017SGR723; Spanish Association Against Cancer (AECC) Scientific Foundation; The ERDF funds-a way to build Europe PI12/00488 PI12/00715 PI12/01270 PI14/00613 PI14/01219 PI15/00069 PI15/00914 PI15/01032 PI17-00092
Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects’ residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44–2.87) to 3 km (1.26; 1.00–1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77–4.00), surface treatment of metals (1.48; 1.08–2.02), glass and mineral fibers (2.06; 1.39–3.07), organic chemical industry (4.80; 3.20–7.20), inorganic chemical industry (6.74; 4.38–10.36), food/beverage sector (3.34; 2.38–4.68), and surface treatment using organic solvents (6.16; 4.06–9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91–14.28), antimony (5.30; 3.45–8.15), naphthalene (3.11; 2.16–4.49), organotin compounds (2.64; 1.76–3.98), manganese (2.53; 1.63–3.93), dichloromethane (2.52; 1.74–3.66), and vanadium (2.49; 1.59–3.91). Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.