@misc{10481/66257,
year = {2020},
url = {http://hdl.handle.net/10481/66257},
abstract = {Background: Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In
Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk
factors, such as environmental exposures, is necessary.
Objectives: To analyze the association between colorectal cancer risk and residential proximity to industries,
according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances,
and specific pollutants released, in the context of a population-based multicase-control study of incident cancer
carried out in Spain (MCC-Spain).
Methods: MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched
by sex, age, and region of residence. Distances were computed from subjects’ residences to each of the 134
industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for
matching variables and other confounders.
Results: Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances
analyzed, from 1 km (2.03; 1.44–2.87) to 3 km (1.26; 1.00–1.59). In general, industries releasing pollutants to
air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR;
95%CI) was found near (≤3 km) production of metals (2.66; 1.77–4.00), surface treatment of metals (1.48;
1.08–2.02), glass and mineral fibers (2.06; 1.39–3.07), organic chemical industry (4.80; 3.20–7.20), inorganic
chemical industry (6.74; 4.38–10.36), food/beverage sector (3.34; 2.38–4.68), and surface treatment using organic solvents (6.16; 4.06–9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km)
industries releasing nonylphenol (9.19; 5.91–14.28), antimony (5.30; 3.45–8.15), naphthalene (3.11;
2.16–4.49), organotin compounds (2.64; 1.76–3.98), manganese (2.53; 1.63–3.93), dichloromethane (2.52;
1.74–3.66), and vanadium (2.49; 1.59–3.91).
Conclusions: Our results support the hypothesis that residing in the proximity of industries may be a risk factor
for colorectal cancer.},
organization = {Scientific Foundation of the Spanish Association Against Cancer (Fundacion Cientifica de la Asociacion Espanola Contra el Cancer (AECC)) 	
EVP-1178/14},
organization = {Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)},
organization = {Instituto de Salud Carlos III

FIS 12/01416},
organization = {Carlos III Institute of Health (ISCIII) grants},
organization = {ERDF funds-a way to build Europe 	
PI08/0533
PI08/1359
PI08/1770
PS09/00773Cantabria
PS09/01286-Leon
PS09/01662-Granada
PS09/01903Valencia
PS09/02078-Huelva
PI11/00226
PI11/01403
PI11/01810
PI11/01889-FEDER
PI11/02213
PI12/00150
PI12/00265},
organization = {Fundacion Caja de Ahorros de Asturias},
organization = {University of Oviedo},
organization = {Junta de Castilla y Leon

LE22A10-2},
organization = {Regional Government of the Basque Country},
organization = {Conselleria de Sanitat of the Generalitat Valenciana 	
AP_061/10},
organization = {Junta de Andalucia

PI-0571-2009
PI-0306-2011
salud201200057018tra},
organization = {Catalan Government DURSI grant 	
2014SGR647},
organization = {European Commission

European Commission Joint Research Centre

FOOD-CT-2006036224-HIWATE},
organization = {La Caixa Foundation

2010ACUP 00310},
organization = {Agency for Management of University and Research Grants (AGAUR) of the Catalan Government 	
2017SGR723},
organization = {Spanish Association Against Cancer (AECC) Scientific Foundation},
organization = {The ERDF funds-a way to build Europe 	
PI12/00488
PI12/00715
PI12/01270
PI14/00613
PI14/01219
PI15/00069
PI15/00914
PI15/01032
PI17-00092},
publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
keywords = {Colorectal cancer},
keywords = {Industrial pollution},
keywords = {MCC-Spain},
keywords = {Case-control study},
keywords = {Residential proximity},
title = {Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)},
doi = {10.1016/j.envint.2020.106055},
author = {García Pérez, Javier and Mirón Pozo, Benito and Jiménez Moleón, José Juan},
}