Polymer/Iron-Based Layered Double Hydroxides as MultifunctionalWound Dressings
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AuthorPires Figueiredo, Mariana; Borrego Sánchez, Ana; García Villén, Fátima; Viseras Iborra, César Antonio
Multifunctional dressingsSkinLocal therapyLayered double hydroxidesDrug release modulationWound healingIntercalation compounds
Figueiredo, M. P., Borrego-Sánchez, A., García-Villén, F., Miele, D., Rossi, S., Sandri, G., ... & Constantino, V. R. L. (2020). Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings. Pharmaceutics, 12(11), 1130. [doi:10.3390/pharmaceutics12111130]
SponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Exterior-BEPE-FAPESP 2018/22782-4; National Council for Scientific and Technological Development (CNPq) CNPq 305446/2017-7; Junta de Andalucía CTS-946 CGL2016-80833-R P18-RT-3786
This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer sca old formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings.