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dc.contributor.authorPires Figueiredo, Mariana
dc.contributor.authorBorrego Sánchez, Ana
dc.contributor.authorGarcía Villén, Fátima
dc.contributor.authorViseras Iborra, César Antonio
dc.identifier.citationFigueiredo, M. P., Borrego-Sánchez, A., García-Villén, F., Miele, D., Rossi, S., Sandri, G., ... & Constantino, V. R. L. (2020). Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings. Pharmaceutics, 12(11), 1130. [doi:10.3390/pharmaceutics12111130]es_ES
dc.description.abstractThis work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer sca old formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings.es_ES
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Exterior-BEPE-FAPESP 2018/22782-4es_ES
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq) CNPq 305446/2017-7es_ES
dc.description.sponsorshipJunta de Andalucía CTS-946 CGL2016-80833-R P18-RT-3786es_ES
dc.rightsAtribución 3.0 España*
dc.subjectMultifunctional dressingses_ES
dc.subjectLocal therapyes_ES
dc.subjectLayered double hydroxideses_ES
dc.subjectDrug release modulationes_ES
dc.subjectWound healinges_ES
dc.subjectIntercalation compoundses_ES
dc.titlePolymer/Iron-Based Layered Double Hydroxides as MultifunctionalWound Dressingses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España