Sociodemographic, clinical and laboratory factors on admission associated with COVID19 mortality in hospitalized patients: A retrospective observational study
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AuthorRivera Izquierdo, Mario; Valero Ubierna, María del Carmen; Sánchez Pérez, María Rosa; Mancera Romero, José; García Martín, Miguel Ángel; Martín de los Reyes, Luis Miguel; Martínez-Ruiz, Virginia; Lardelli Claret, Pablo; Jiménez Mejías, Eladio
Public Library of Science
Rivera-Izquierdo M, del Carmen ValeroUbierna M, R-delAmo JL, Fernández-García MA´, Martínez-Diz S, Tahery-Mahmoud A, et al. (2020) Sociodemographic, clinical and laboratory factors on admission associated with COVID-19 mortality in hospitalized patients: A retrospective observational study. PLoS ONE 15(6): e0235107. [https://doi.org/10.1371/journal.pone.0235107]
SponsorshipFondos Estructurales de la Union Europea (FEDER); Unit of Excellence on Exercise and Health (UCEES), University of Granada
Background To identify and quantify associations between baseline characteristics on hospital admission and mortality in patients with COVID-19 at a tertiary hospital in Spain. Methods and findings This retrospective case series included 238 patients hospitalized for COVID-19 at Hospital Universitario Clı´nico San Cecilio (Granada, Spain) who were discharged or who died. Electronic medical records were reviewed to obtain information on sex, age, personal antecedents, clinical features, findings on physical examination, and laboratory results for each patient. Associations between mortality and baseline characteristics were estimated as hazard ratios (HR) calculated with Cox regression models. Series mortality was 25.6%. Among patients with dependence for basic activities of daily living, 78.7% died, and among patients residing in retirement homes, 80.8% died. The variables most clearly associated with a greater hazard of death were age (3% HR increase per 1-year increase in age; 95%CI 1–6), diabetes mellitus (HR 2.42, 95%CI 1.43–4.09), SatO2/ FiO2 ratio (43% HR reduction per 1-point increase; 95%CI 23–57), SOFA score (19% HR increase per 1-point increase, 95%CI 5–34) and CURB-65 score (76% HR increase per 1- point increase, 95%CI 23–143). Conclusions The patients residing in retirement homes showed great vulnerability. The main baseline factors that were independently associated with mortality in patients hospitalized for COVID-19 were older age, diabetes mellitus, low SatO2/FiO2 ratio, and high SOFA and CURB-65 scores.