Sociodemographic, clinical and laboratory factors on admission associated with COVID19 mortality in hospitalized patients: A retrospective observational study
Metadatos
Mostrar el registro completo del ítemAutor
Rivera Izquierdo, Mario; Valero Ubierna, María del Carmen; Sánchez Pérez, María Rosa; Mancera Romero, José; García Martín, Miguel Ángel; Martín de los Reyes, Luis Miguel; Martínez Ruiz, Virginia Ana; Lardelli Claret, Pablo; Jiménez Mejías, EladioEditorial
Public Library of Science
Materia
COVID-19
Fecha
2020-06Referencia bibliográfica
Rivera-Izquierdo M, del Carmen ValeroUbierna M, R-delAmo JL, Fernández-García MA´, Martínez-Diz S, Tahery-Mahmoud A, et al. (2020) Sociodemographic, clinical and laboratory factors on admission associated with COVID-19 mortality in hospitalized patients: A retrospective observational study. PLoS ONE 15(6): e0235107. [https://doi.org/10.1371/journal.pone.0235107]
Patrocinador
Fondos Estructurales de la Union Europea (FEDER); Unit of Excellence on Exercise and Health (UCEES), University of GranadaResumen
Background
To identify and quantify associations between baseline characteristics on hospital admission and mortality in patients with COVID-19 at a tertiary hospital in Spain.
Methods and findings
This retrospective case series included 238 patients hospitalized for COVID-19 at Hospital
Universitario Clı´nico San Cecilio (Granada, Spain) who were discharged or who died. Electronic medical records were reviewed to obtain information on sex, age, personal antecedents, clinical features, findings on physical examination, and laboratory results for each
patient. Associations between mortality and baseline characteristics were estimated as hazard ratios (HR) calculated with Cox regression models.
Series mortality was 25.6%. Among patients with dependence for basic activities of daily
living, 78.7% died, and among patients residing in retirement homes, 80.8% died. The variables most clearly associated with a greater hazard of death were age (3% HR increase per
1-year increase in age; 95%CI 1–6), diabetes mellitus (HR 2.42, 95%CI 1.43–4.09), SatO2/
FiO2 ratio (43% HR reduction per 1-point increase; 95%CI 23–57), SOFA score (19% HR
increase per 1-point increase, 95%CI 5–34) and CURB-65 score (76% HR increase per 1-
point increase, 95%CI 23–143).
Conclusions
The patients residing in retirement homes showed great vulnerability. The main baseline
factors that were independently associated with mortality in patients hospitalized for
COVID-19 were older age, diabetes mellitus, low SatO2/FiO2 ratio, and high SOFA and
CURB-65 scores.