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dc.contributor.authorOlicón Hernández, Darío Rafael
dc.contributor.authorOrtúzar, Maite
dc.contributor.authorPozo Llorente, Clementina 
dc.contributor.authorGonzález López, Jesús Juan 
dc.date.accessioned2020-07-15T11:48:12Z
dc.date.available2020-07-15T11:48:12Z
dc.date.issued2020-04
dc.identifier.citationOlicón-Hernández, D. R., Ortúzar, M., Pozo, C., González-López, J., & Aranda, E. (2020). Metabolic Capability of Penicillium oxalicum to Transform High Concentrations of Anti-Inflammatory and Analgesic Drugs. Applied Sciences, 10(7), 2479. [doi:10.3390/app10072479]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/62985
dc.descriptionOlicón-Hernández would like to thank Consejo Nacional de Ciencia y Tecnología (CONACyT) for the postdoc fellowships (231581/454815). E. A. would like to thank the Ministry of Economy and Competitiveness (MINECO) and European Regional Development Fund (ERDF) funds [RYC-2013-12481] and [CTM- 2017-84332, MINECO/AEI/FEDER, UE].es_ES
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) and analgesics are two of the most employed drug groups around the world due to their use in the treatment of edema and pain. However, they also present an ecological challenge because they are considered as potential water pollutants. In this work, the biodegradation of four NSAIDs (diclofenac, ibuprofen, naproxen and ketoprofen) and one analgesic (acetaminophen) at 50 µM (initial concentration) by Penicillium oxalicum, at both flask and bioreactor bench scales, was evaluated. An important co-metabolic mechanism as part of the global bioremediation process for the elimination of these drugs was observed, as in some cases it was necessary to supplement glucose to achieve a 100% removal rate: both individually and as a complex mixture. Identical behavior in the implementation of a fluidized bench-scale batch bioreactor, inoculated with pellets of this fungus and the complex mix of the drugs, was observed. The role of the cytochrome P450 enzymes (CYP) in the biodegradation of the drugs mix were evidenced by the observation of hydroxylated by-products. The results on the reduction of toxicity (micro and phyto) were not conclusive; however, a reduction in phytotoxicity was detected.es_ES
dc.description.sponsorshipMINECO-ERDF funds [MINECO/AEI/ERDF, UE] RYC-2013-12481 CTM-2017-84332es_ES
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologia (CONACyT) 231581/454815es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAscomycetes es_ES
dc.subjectAnalgesics es_ES
dc.subjectEmerging contaminantses_ES
dc.subjectBiodegradation es_ES
dc.subjectNon-steroidal anti-inflammatory drugses_ES
dc.subjectPenicillium oxalicumes_ES
dc.titleMetabolic Capability of Penicillium oxalicum to Transform High Concentrations of Anti-Inflammatory and Analgesic Drugses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/app10072479


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Atribución 3.0 España
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