Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction
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Metabolic syndromeProgrammingAdiponectinLeptinResistinPrematurityExtrauterine growth restriction
Ordóñez-Díaz, M. D., Gil-Campos, M., Flores-Rojas, K., Muñoz-Villanueva, M. C., Aguilera-García, C. M., Torre-Aguilar, M. J. D. L., & Pérez-Navero, J. L. (2020). Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction. Nutrients, 12(4), 1201. [doi:10.3390/nu12041201]
SponsorshipThis study was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (Iþ DþI), Instituto de Salud Carlos III-Fondo de Investigación Sanitaria Project No. PI13/01245 from the Spanish Ministry of Health and Consumer Affairs and co-financed by the Consejería de Innovación y Ciencia, Junta de Andalucía, PI-0480-2012, Spain. The funding bodies did not partake in the design, collection, analyses or interpretation of the data or in writing the manuscript.
Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (µg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.