Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases
Metadatos
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MDPI
Date
2020-04Referencia bibliográfica
Gálvez-Ontiveros, Y., Páez, S., Monteagudo, C., & Rivas, A. (2020). Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases. Nutrients, 12(4), 1158. [doi:10.3390/nu12041158]
Patrocinador
This work was carried out within the frame of GP/EFSA/ENCO/380 2018/03/G04: OBEMIRISK: Knowledge platform for assessing the risk of Bisphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers. This research was also funded by Plan Estatal de I+D+I 2013-2016, Proyecto cofinanciado FEDER-ISCIII PI17/01758, Proyecto cofinanciado FEDER-Consejería de Salud y Familias, Junta de Andalucía PE-0250-2019 and by Fundación Mapfre MAPFRE2018.Résumé
Endocrine disruptors (EDCs) have been associated with the increased incidence of
metabolic disorders. In this work, we conducted a systematic review of the literature in order
to identify the current knowledge of the interactions between EDCs in food, the gut microbiota,
and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces
a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and
associated genes, enzymes, and metabolites involved in EDC metabolism. The products and
by-products released following the microbial metabolism of EDCs can be taken up by the host;
therefore, changes in the composition of the microbiota and in the production of microbial metabolites
could have a major impact on host metabolism and the development of diseases. The remediation of
EDC-induced changes in the gut microbiota might represent an alternative course for the treatment
and prevention of metabolic diseases.