Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and Prostate Cancer
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AuthorOlmedo Requena, María Rocío; Lozano Lorca, Macarena; Salcedo Bellido, Inmaculada; Jiménez Pacheco, Antonio; Vázquez Alonso, Fernando; García Caballos, Marta; Sánchez Pérez, María José; Jiménez Moleón, José Juan
Prostate cancerWCRF/AICR 2018 recommendationsNutrition-based guidelinesCase-control study
Rocío, O. R., Macarena, L. L., Inmaculada, S. B., Antonio, J. P., Fernando, V. A., Marta, G. C., ... & José-Juan, J. M. (2020). Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and Prostate Cancer. Nutrients, 12(3), 768. [doi:10.3390/nu12030768]
SponsorshipThis research was funded by Regional Ministry of Health of Andalusia/Consejería de Salud of the Junta de Andalucía (PI-0514-2016) and Instituto de Salud Carlos III-FEDER (PI15/00914).
The etiology of prostate cancer (PCa) remains largely unknown. Compliance with the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) cancer prevention recommendations and its relationship to PCa was evaluated. A total of 398 incident PCa cases and 302 controls were included. The selection criteria for both cases and controls were: (i) age between 40–80 years; and (ii) residence in the coverage area of the reference hospitals for 6 months or more prior to recruitment. A score to measure the compliance with the recommendations of 2018 WCRC/AICR criteria was built. The level of compliance was used as a continuous variable and categorized in terciles. The aggressiveness of PCa was determined according to the ISUP classification. Adjusted odds ratios (aOR) and their 95% confidence intervals (95% CI) were estimated using multivariable logistic regression models. A slight protective tendency was observed between the level of compliance with the preventive recommendations and PCa risk, aOR = 0.81 (95% CI 0.69–0.96) for the total cases of PCa. This association also was observed when the aggressiveness was considered. In addition, limiting consumption of “fast foods”, sugar-sweetened drinks, and alcohol were independently associated with lower risk of PCa.
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