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dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorOsorio Ruiz, María Estrella 
dc.contributor.authorSánchez Aguilera, Fátima 
dc.contributor.authorMuñoz Soto, Esther
dc.contributor.authorToledano-Osorio, Manuel
dc.contributor.authorLópez López, Modesto Torcuato 
dc.contributor.authorMedina Castillo, Antonio Luis 
dc.contributor.authorCarmona-Carmona, Álvaro
dc.contributor.authorOsorio Ruiz, Raquel
dc.identifier.citationToledano M., Osorio E., Aguilera F.S., Muñoz-Soto E., Toledano-Osorio M., López-López M.T., Medina-Castillo A.L., Carrasco-Carmona Á., Osorio R. Polymeric nanoparticles for endodontic therapy (2020) Journal of the Mechanical Behavior of Biomedical Materials, 103.: 103606es_ES
dc.description.abstractThe effectiveness of novel polymeric nanoparticles (NPs) application in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment was evaluated. The effect of undoped NPs, zinc, calcium and doxycycline-doped NPs (Zn-NPs, Ca-NPs and D-NPs, respectively) was tested in radicular dentin. A control group without NPs was included. Radicular dentin was assessed for fluid filtration. Dentin remineralization was analyzed by scanning and transmission electron microscopy, energy-dispersive analysis, AFM, Young´s modulus (Ei), Nano DMA, Raman, and X-Ray Diffraction analysis. Ca-NPs and Zn-NPs treated dentin exhibited the lowest microleakage with hermetically sealed dentinal tubules and a zinc-based salt generation onto dentin. Zn-NPs favored crystallinity and promoted the highest Ei and functional remineralization at the apical dentin, generating differences between the values of complex modulus among groups. Ca-NPs produced closure of tubules and porosities at the expense of a relative mineral amorphization, without creating zones of stress concentration. The highest sealing efficacy was obtained in Zn-NPs-treated samples, along with the highest values of Young´s modulus and dentin mineralization. These high values of Ei were obtained by closing voids, cracks, pores and tubules, and by strengthening the root dentin. When using undoped NPs or Ca-NPs, deposition of minerals occurred, but radicular dentin was not mechanically reinforced. Therefore, application of Zn-NPs in endodontically treated teeth previous to the canal filling is encouraged.es_ES
dc.description.sponsorshipThis work was supported by the Ministry of Economy and Competitiveness and European Regional Development Fund [MAT2017-85999P MINECO/AEI/FEDER/UE].es_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectsealing abilityes_ES
dc.titlePolymeric nanoparticles for endodontic therapyes_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España