Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends
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AuthorHernández-Mesa, Maykel; Ropartz, David; García Campaña, Ana María; Rogniaux, Hélène; Dervilly Pinel, Gaud; Le Bizec, Bruno
Food qualityFood compositionFood process controlFood authenticationFood safety
Hernández-Mesa, M., Ropartz, D., García-Campaña, A. M., Rogniaux, H., Dervilly-Pinel, G., & Le Bizec, B. (2019). Ion mobility spectrometry in food analysis: principles, current applications and future trends. Molecules, 24(15), 2706.
SponsorshipM.H.-M. was granted a postdoctoral fellowship (University Research Plan, Program “Perfeccionamiento de doctores en el extranjero 2017”) by the University of Granada (Spain).
In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical separation technique, especially due to the commercialization of ion mobility mass spectrometers. Its applicability has been extended beyond classical applications such as the determination of chemical warfare agents and nowadays it is widely used for the characterization of biomolecules (e.g., proteins, glycans, lipids, etc.) and, more recently, of small molecules (e.g., metabolites, xenobiotics, etc.). Following this trend, the interest in this technique is growing among researchers from different fields including food science. Several advantages are attributed to IMS when integrated in traditional liquid chromatography (LC) and gas chromatography (GC) mass spectrometry (MS) workflows: (1) it improves method selectivity by providing an additional separation dimension that allows the separation of isobaric and isomeric compounds; (2) it increases method sensitivity by isolating the compounds of interest from background noise; (3) and it provides complementary information to mass spectra and retention time, the so-called collision cross section (CCS), so compounds can be identified with more confidence, either in targeted or non-targeted approaches. In this context, the number of applications focused on food analysis has increased exponentially in the last few years. This review provides an overview of the current status of IMS technology and its applicability in different areas of food analysis (i.e., food composition, process control, authentication, adulteration and safety).