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dc.contributor.authorFernández Ochoa, Álvaro
dc.contributor.authorCázares Camacho, Rosario
dc.contributor.authorBorrás-Linares, Isabel
dc.contributor.authorDomínguez Ávila, J. Abraham
dc.contributor.authorSegura Carretero, Antonio 
dc.contributor.authorGonzález Aguilar, Gustavo Adolfo
dc.identifier.citationFernández-Ochoa, Á., Cázares-Camacho, R., Borrás-Linares, I., Domínguez-Avila, J. A., Segura-Carretero, A., & González-Aguilar, G. A. (2020). Evaluation of metabolic changes in liver and serum of streptozotocin-induced diabetic rats after Mango diet supplementation. Journal of Functional Foods, 64, 103695.es_ES
dc.description.abstractMango consumption has shown bioactive properties against several diseases like diabetes, therefore, we evaluated how a mango-supplemented diet affects metabolic pathways in diabetic rats. Serum and liver samples were collected from 26 rats divided into 3 groups (healthy, untreated diabetic and mango-treated diabetic) after dietary intervention and analysed using an LC-MS untargeted metabolomic strategy. Twenty-six and 29 metabolites in serum and liver were potentially annotated, showing significant differences among groups. Several affected pathways were due to the disease state [fatty acids (i.e. palmitoleic, linolenic, stearidonic, eicosapentaenoic, docosahexaenoic acids and others), bile acids (i.e. glycocholic acid) and amino acids (i.e. leucine, isoleucine and valine)], and others due to mango supplementation (increased hepatic bioaccumulation of euxanthone, a mangiferin metabolite, and increased glutathione concentration). These results suggest that a mango-supplemented diet exerted a significant antioxidant effect in the liver of diabetic rats, likely due to its phenolic compounds, like mangiferin and its metabolites.es_ES
dc.description.sponsorshipThe author AFO received support from the Spanish Ministry of Education, Culture and Sports (FPU grant 14/03992). RCC is thankful to CIAD-CONACYT for the scholarship received. We thank CONACYTMexico for financial support of the project Ciencia de la Frontera (P00054044). This study is considered as part of the collaboration that ASC and GAG have in the network (ALSUB-CYTED, 118RT0543).es_ES
dc.publisherElsevier BVes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subject'Ataulfo’ mangoes_ES
dc.subjectMangifera indica Les_ES
dc.subjectDiabetes mellituses_ES
dc.subjectMass spectrometry es_ES
dc.titleEvaluation of metabolic changes in liver and serum of streptozotocininduced diabetic rats after Mango diet supplementationes_ES

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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España