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dc.contributor.authorGarcía Zea, Jerson Alexander
dc.contributor.authorHerrán Moreno, Roberto De La 
dc.contributor.authorRobles Rodríguez, Francisca 
dc.contributor.authorNavajas Pérez, Rafael 
dc.contributor.authorRuiz Rejón, Carmelo 
dc.date.accessioned2020-01-16T10:10:05Z
dc.date.available2020-01-16T10:10:05Z
dc.date.issued2019-01-11
dc.identifier.citationGarcía-Zea JA, de la Herrán R, Robles Rodríguez F, Navajas-Pérez R, Ruiz Rejón C. 2019. Detection and variability analyses of CRISPR-like loci in the H. pylori genome. PeerJ 7:e6221es_ES
dc.identifier.urihttp://hdl.handle.net/10481/58809
dc.description.abstractHelicobacter pylori is a human pathogenic bacterium with a high genomic plasticity. Although the functional CRISPR-Cas system has not been found in its genome, CRISPR-like loci have been recently identified. In this work, 53 genomes from different geographical areas are analyzed for the search and analysis of variability of this type of structure. We confirm the presence of a locus that was previously described in the VlpC gene in al lgenomes, and we characterize new CRISPR-like loci in other genomic locations. By studying the variability and gene location of these loci, the evolution and the possible roles of these sequences are discussed. Additionally, the usefulness of this type of sequences as a phylogenetic marker has been demonstrated, associating the different strains by geographical area.es_ES
dc.language.isoenges_ES
dc.publisherPeerJes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectVariability CRISPR-likees_ES
dc.subjectVlpC genees_ES
dc.subjectPhylogenetic markeres_ES
dc.subjectHelicobacter pylories_ES
dc.titleDetection and variability analyses of CRISPR-like loci in the H. pylori genomees_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.7717/peerj.6221


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