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dc.contributor.authorGarrido Navas, María del Carmen 
dc.contributor.authorMiguel-Pérez, Diego de
dc.contributor.authorExpósito Hernández, José 
dc.contributor.authorBayarri Lara, Clara Isabel
dc.contributor.authorAmezcua, Víctor
dc.contributor.authorOrtigosa Palomo, Alba
dc.contributor.authorValdivia, Javier
dc.contributor.authorGuerrero, Rosa
dc.contributor.authorGarcía Puche, José Luis 
dc.contributor.authorLorente Acosta, José Antonio 
dc.contributor.authorSerrano Fernández, María José
dc.identifier.citationGarrido-Navas, C., de Miguel-Pérez, D., Exposito-Hernandez, J., Bayarri, C., Amezcua, V., Ortigosa, A., ... & Serrano, M. J. (2019). Cooperative and Escaping Mechanisms between Circulating Tumor Cells and Blood Constituents. Cells, 8(11), 1382.es_ES
dc.description.abstractMetastasis is the leading cause of cancer-related deaths and despite measurable progress in the field, underlying mechanisms are still not fully understood. Circulating tumor cells (CTCs) disseminate within the bloodstream, where most of them die due to the attack of the immune system. On the other hand, recent evidence shows active interactions between CTCs and platelets, myeloid cells, macrophages, neutrophils, and other hematopoietic cells that secrete immunosuppressive cytokines, which aid CTCs to evade the immune system and enable metastasis. Platelets, for instance, regulate inflammation, recruit neutrophils, and cause fibrin clots, which may protect CTCs from the attack of Natural Killer cells or macrophages and facilitate extravasation. Recently, a correlation between the commensal microbiota and the inflammatory/immune tone of the organism has been stablished. Thus, the microbiota may affect the development of cancer-promoting conditions. Furthermore, CTCs may suffer phenotypic changes, as those caused by the epithelial–mesenchymal transition, that also contribute to the immune escape and resistance to immunotherapy. In this review,we discuss the findings regarding the collaborative biological events among CTCs, immune cells, and microbiome associated to immune escape and metastatic progression.es_ES
dc.rightsAtribución 3.0 España*
dc.subjectCirculating tumor cellses_ES
dc.subjectTumor cell disseminationes_ES
dc.subjectImmune systemes_ES
dc.titleCooperative and Escaping Mechanisms between Circulating Tumor Cells and Blood Constituentses_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España