Cooperative and Escaping Mechanisms between Circulating Tumor Cells and Blood Constituents
Metadatos
Mostrar el registro completo del ítemAutor
Garrido Navas, María del Carmen; Miguel-Pérez, Diego de; Expósito Hernández, José; Bayarri Lara, Clara Isabel; Amezcua, Víctor; Ortigosa Palomo, Alba; Valdivia, Javier; Guerrero, Rosa; García Puche, José Luis; Lorente Acosta, José Antonio; Serrano Fernández, María JoséEditorial
MDPI
Materia
Circulating tumor cells Tumor cell dissemination Immune system Microbiome
Fecha
2019-11-03Referencia bibliográfica
Garrido-Navas, C., de Miguel-Pérez, D., Exposito-Hernandez, J., Bayarri, C., Amezcua, V., Ortigosa, A., ... & Serrano, M. J. (2019). Cooperative and Escaping Mechanisms between Circulating Tumor Cells and Blood Constituents. Cells, 8(11), 1382.
Resumen
Metastasis is the leading cause of cancer-related deaths and despite measurable progress
in the field, underlying mechanisms are still not fully understood. Circulating tumor cells (CTCs)
disseminate within the bloodstream, where most of them die due to the attack of the immune system.
On the other hand, recent evidence shows active interactions between CTCs and platelets, myeloid cells,
macrophages, neutrophils, and other hematopoietic cells that secrete immunosuppressive cytokines,
which aid CTCs to evade the immune system and enable metastasis. Platelets, for instance, regulate
inflammation, recruit neutrophils, and cause fibrin clots, which may protect CTCs from the attack
of Natural Killer cells or macrophages and facilitate extravasation. Recently, a correlation between the
commensal microbiota and the inflammatory/immune tone of the organism has been stablished. Thus,
the microbiota may affect the development of cancer-promoting conditions. Furthermore, CTCs may
suffer phenotypic changes, as those caused by the epithelial–mesenchymal transition, that also contribute
to the immune escape and resistance to immunotherapy. In this review,we discuss the findings regarding
the collaborative biological events among CTCs, immune cells, and microbiome associated to immune
escape and metastatic progression.