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dc.contributor.authorMelguizo Rodríguez, Lucía Raquel 
dc.contributor.authorCostela Ruiz, Víctor Javier 
dc.contributor.authorManzano Moreno, Francisco Javier
dc.contributor.authorIllescas Montes, Rebeca 
dc.contributor.authorRamos Torrecillas, Javier 
dc.contributor.authorGarcía Martínez, Olga 
dc.contributor.authorRuiz Rodríguez, Concepción 
dc.date.accessioned2019-11-18T12:39:46Z
dc.date.available2019-11-18T12:39:46Z
dc.date.issued2018-08-14
dc.identifier.citationMelguizo-Rodríguez, L., Costela-Ruiz, V. J., Manzano-Moreno, F. J., Illescas-Montes, R., Ramos-Torrecillas, J., García-Martínez, O., & Ruiz, C. (2018). Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts. PeerJ, 6, e5415.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/57958
dc.description.abstractNonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in clinical practice, which can have adverse effects on the osteoblast. The objective of this study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene expression of different markers related to osteoblast maturation and function when treated in vitro with different NSAIDs. Expression of RUNX-2, COL-I, OSX, was reduced by treatment with all studied NSAIDs, OSC expression was reduced by all NSAIDs except for ketoprofen, naproxen, or piroxicam. Expression of BMP-7 was reduced by all NSAIDs; BMP-2 was reduced by all except for naproxen. In general, NSAID treatment increased the expression of TGF- 1, but not of its receptors (TGF -R1, TGF -R2, and TFG -R3), which was either unchanged or reduced by the treatment. These data confirm that NSAIDs can affect osteoblast physiology, suggesting their possible impact on bone.es_ES
dc.description.sponsorshipThis study was supported by research group BIO277 (Junta de Andalucía) and Department of Nursing (University of Granada). The work outlined in this article has been supported by the Spanish Ministry of Education under FPU fellowship reference FPU15-05635 and FPU16-04141.es_ES
dc.language.isoenges_ES
dc.publisherPeerJes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectBone tissuees_ES
dc.subjectHuman osteoblastses_ES
dc.subjectDifferentiationes_ES
dc.subjectGene expressiones_ES
dc.subjectNSAIDses_ES
dc.titleRepercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblastses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.7717/peerj.5415


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España