Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts
Metadatos
Afficher la notice complèteAuteur
Melguizo Rodríguez, Lucía Raquel; Costela Ruiz, Víctor Javier; Manzano Moreno, Francisco Javier; Illescas Montes, Rebeca; Ramos Torrecillas, Javier; García Martínez, Olga; Ruiz Rodríguez, ConcepciónEditorial
PeerJ
Materia
Bone tissue Human osteoblasts Differentiation Gene expression NSAIDs
Date
2018-08-14Referencia bibliográfica
Melguizo-Rodríguez, L., Costela-Ruiz, V. J., Manzano-Moreno, F. J., Illescas-Montes, R., Ramos-Torrecillas, J., García-Martínez, O., & Ruiz, C. (2018). Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts. PeerJ, 6, e5415.
Patrocinador
This study was supported by research group BIO277 (Junta de Andalucía) and Department of Nursing (University of Granada). The work outlined in this article has been supported by the Spanish Ministry of Education under FPU fellowship reference FPU15-05635 and FPU16-04141.Résumé
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used in
clinical practice, which can have adverse effects on the osteoblast. The objective of this
study was to determine the effect of NSAIDs on the osteoblast by analyzing the gene
expression of different markers related to osteoblast maturation and function when
treated in vitro with different NSAIDs. Expression of RUNX-2, COL-I, OSX, was reduced by treatment with all studied
NSAIDs, OSC expression was reduced by all NSAIDs except for ketoprofen, naproxen,
or piroxicam. Expression of BMP-7 was reduced by all NSAIDs; BMP-2 was reduced by
all except for naproxen. In general, NSAID treatment increased the expression of TGF-
1, but not of its receptors (TGF -R1, TGF -R2, and TFG -R3), which was either
unchanged or reduced by the treatment. These data confirm that NSAIDs can affect osteoblast physiology, suggesting
their possible impact on bone.