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dc.contributor.authorHidalgo Rodríguez, María Del Carmen 
dc.contributor.authorLuna-Sánchez, Marta
dc.contributor.authorHidalgo Gutiérrez, Agustín 
dc.contributor.authorBarriocanal Casado, Eliana 
dc.contributor.authorMascaraque Molina, Cristina 
dc.contributor.authorAcuña Castroviejo, Darío 
dc.contributor.authorRivera Sánchez, Margarita
dc.contributor.authorEscames Rosa, Germaine 
dc.contributor.authorLópez, Luis
dc.date.accessioned2019-11-14T10:01:01Z
dc.date.available2019-11-14T10:01:01Z
dc.date.issued2018-09-18
dc.identifier.citationRodríguez-Hidalgo, M., Luna-Sánchez, M., Hidalgo-Gutiérrez, A., Barriocanal-Casado, E., Mascaraque, C., Acuña-Castroviejo, D., ... & López, L. C. (2018). Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis. Scientific reports, 8(1), 14013.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/57884
dc.description.abstractMitohormesis is an adaptive response induced by a mild mitochondrial stress that promotes longevity and metabolic health in different organisms. This mechanism has been proposed as the cause of the increase in the survival in Coq7+/− (Mclk1+/−) mice, which show hepatic reduction of COQ7, early mitochondrial dysfunction and increased oxidative stress. Our study shows that the lack of COQ9 in Coq9Q95X mice triggers the reduction of COQ7, COQ6 and COQ5, which results in an increase in life expectancy. However, our results reveal that the hepatic CoQ levels are not decreased and, therefore, neither mitochondrial dysfunction or increased oxidative stress are observed in liver of Coq9Q95X mice. These data point out the tissue specific differences in CoQ biosynthesis. Moreover, our results suggest that the effect of reduced levels of COQ7 on the increased survival in Coq9Q95X mice may be due to mitochondrial mechanisms in non-liver tissues or to other unknown mechanisms.es_ES
dc.description.sponsorshipThis work was supported by grants from Ministerio de Economía Competitividad, Spain, and the ERDF (Grant Number SAF2015-65786-R), from the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (grant number P10-CTS-6133) and from the University of Granada (grant reference “UNETE”, UCE-PP2017-06). AHG is a “FPU fellow” from the Ministerio de Educación Cultura y Deporte, Spain. MLS was a predoctoral fellow from the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía. LCL was supported by the “Ramón y Cajal” National Programme, Ministerio de Economía y Competitividad, Spain (RYC-2011-07643).es_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleReduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41598-018-32190-y


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España