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Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial
dc.contributor.author | Soriano‑Maldonado, Alberto | |
dc.contributor.author | Morillas de Laguno, Pablo | |
dc.contributor.author | Mario Sabio, José | |
dc.contributor.author | Gavilán-Carrera, Blanca | |
dc.contributor.author | Rosales-Castillo, Antonio | |
dc.contributor.author | Montalbán-Méndez, Cristina | |
dc.contributor.author | Sáez Urán, Luis Manuel | |
dc.contributor.author | Callejas Rubio, José Luis | |
dc.contributor.author | Vargas-Hitos, José Antonio | |
dc.date.accessioned | 2019-04-12T07:23:08Z | |
dc.date.available | 2019-04-12T07:23:08Z | |
dc.date.issued | 2018-10-24 | |
dc.identifier.citation | Soriano‑Maldonado, A.[ et al.]. Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial. J. Clin. Med. 2018, 7, 477; doi:10.3390/jcm7120477. | es_ES |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/10481/55419 | |
dc.description.abstract | This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions X 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN- α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI -0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE. | es_ES |
dc.description.sponsorship | This work was supported by Fundación para la Investigación Biosanitaria de Andalucía Oriental (grant number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017). BG-C was supported by the Spanish Ministry of Education (FPU15/00002). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Exercise | es_ES |
dc.subject | Physical fitness | es_ES |
dc.subject | Aerobic fitness | es_ES |
dc.subject | Physical function | es_ES |
dc.subject | Pulse wave velocity | es_ES |
dc.subject | Autoimmune diseases | es_ES |
dc.subject | Vascular health | es_ES |
dc.subject | Atherosclerosis | es_ES |
dc.subject | Lupus | es_ES |
dc.subject | Inflammatory disease | es_ES |
dc.title | Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |