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dc.contributor.authorSoriano‑Maldonado, Alberto
dc.contributor.authorMorillas de Laguno, Pablo
dc.contributor.authorMario Sabio, José
dc.contributor.authorGavilán-Carrera, Blanca
dc.contributor.authorRosales-Castillo, Antonio
dc.contributor.authorMontalbán-Méndez, Cristina
dc.contributor.authorSáez Urán, Luis Manuel
dc.contributor.authorCallejas Rubio, José Luis 
dc.contributor.authorVargas-Hitos, José Antonio
dc.identifier.citationSoriano‑Maldonado, A.[ et al.]. Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial. J. Clin. Med. 2018, 7, 477; doi:10.3390/jcm7120477.es_ES
dc.description.abstractThis study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions X 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN- α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI -0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.es_ES
dc.description.sponsorshipThis work was supported by Fundación para la Investigación Biosanitaria de Andalucía Oriental (grant number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017). BG-C was supported by the Spanish Ministry of Education (FPU15/00002).es_ES
dc.rightsAtribución 3.0 España*
dc.subjectExercise es_ES
dc.subjectPhysical fitnesses_ES
dc.subjectAerobic fitnesses_ES
dc.subjectPhysical functiones_ES
dc.subjectPulse wave velocityes_ES
dc.subjectAutoimmune diseases es_ES
dc.subjectVascular healthes_ES
dc.subjectAtherosclerosis es_ES
dc.subjectInflammatory diseasees_ES
dc.titleEffects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Triales_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España