Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial
Metadatos
Afficher la notice complèteAuteur
Soriano‑Maldonado, Alberto; Morillas de Laguno, Pablo; Mario Sabio, José; Gavilán-Carrera, Blanca; Rosales-Castillo, Antonio; Montalbán-Méndez, Cristina; Sáez Urán, Luis Manuel; Callejas Rubio, José Luis; Vargas-Hitos, José AntonioEditorial
MDPI
Materia
Exercise Physical fitness Aerobic fitness Physical function Pulse wave velocity Autoimmune diseases Vascular health Atherosclerosis Lupus Inflammatory disease
Date
2018-10-24Referencia bibliográfica
Soriano‑Maldonado, A.[ et al.]. Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial. J. Clin. Med. 2018, 7, 477; doi:10.3390/jcm7120477.
Patrocinador
This work was supported by Fundación para la Investigación Biosanitaria de Andalucía Oriental (grant number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017). BG-C was supported by the Spanish Ministry of Education (FPU15/00002).Résumé
This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary
outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in
women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with
SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised
12 weeks of aerobic exercise (2 sessions X 75 min/week) between 40–75% of the individual’s heart
rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity
(PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha
[TFN- α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were
obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no
between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI
-0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison
to the control group, the exercise group significantly increased cardiorespiratory fitness (median
difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of
progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial
stiffness, inflammation, or oxidative stress in women with SLE.