Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications
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AutorSánchez Moreno, Paola; Vicente Álvarez-Manzaneda, Juan De; Nardecchia, Stefania; Marchal Corrales, Juan Antonio; Boulaiz Tassi, Houria
Thermo-sensitive nanomaterialsPNIPAmThermo-responsive polymersLCSTThermochromism
Sánchez-Moreno, P. [et al.]. Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications. Nanomaterials 2018, 8, 935; doi:10.3390/nano8110935.
PatrocinadorThis research was supported by the Fundación Mutua Madrileña (project FMM-AP16683-2017), Consejería de Salud Junta de Andalucía (PI-0089-2017), Instituto de Salud Carlos III (FEDER funds PIE16/00045), MINECO MAT2015-63644-C2-R, MAT 2016-78778-R, PCIN-2015-051 projects (Spain), European Regional Development Fund (ERDF) and from the Chair “Doctors Galera-Requena in cancer stem cell research”.
Progress in nanotechnology has enabled us to open many new fronts in biomedical research by exploiting the peculiar properties of materials at the nanoscale. The thermal sensitivity of certain materials is a highly valuable property because it can be exploited in many promising applications, such as thermo-sensitive drug or gene delivery systems, thermotherapy, thermal biosensors, imaging, and diagnosis. This review focuses on recent advances in thermo-sensitive nanomaterials of interest in biomedical applications. We provide an overview of the different kinds of thermoresponsive nanomaterials, discussing their potential and the physical mechanisms behind their thermal response. We thoroughly review their applications in biomedicine and finally discuss the current challenges and future perspectives of thermal therapies.