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dc.contributor.authorErenas Rodríguez, Miguel María
dc.contributor.authorOrtiz Gómez, Inmaculada
dc.contributor.authorOrbe Payá, Ignacio De 
dc.contributor.authorHernández-Alonso, Daniel
dc.contributor.authorBallester, Pablo
dc.contributor.authorBlondeau, Pascal
dc.contributor.authorAndrade, Francisco J
dc.contributor.authorSalinas-Castillo, Alfonso
dc.contributor.authorCapitán Vallvey, Luis Fermín
dc.identifier.citationErenas, Miguel, M. [et al.] Ionophore-Based Optical Sensor for Urine Creatinine Determination. ACS Sens. 2019, 4, 421−426es_ES
dc.description.abstractCreatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pKa values of creatininium (pKa 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10−5 to 1 × 10−2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-to-sensor reproducibility (RSD, 5.1−6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé’s reactiones_ES
dc.description.sponsorshipMINECO (CTQ2016-78754-C2-1-R)es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness and European Regional Development Fund (ERDF) CTQ2016-77128-Res_ES
dc.description.sponsorshipMINECO (CTQ2017-84319-P)es_ES
dc.description.sponsorshipSevero Ochoa Excellence Accreditation 2014-2018 SEV-2013-0319es_ES
dc.description.sponsorshipFEDER funds (Project CTQ2017- 84319-P)es_ES
dc.description.sponsorshipCERCA Programme/Generalitat de Catalunya and AGAUR (2017 SGR 1123)es_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licenseen_EN
dc.subjectDisposable sensores_ES
dc.subjectHost-guest chemistryes_ES
dc.titleIonophore-Based Optical Sensor for Urine Creatinine Determinationes_ES

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